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Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease.
Muthaiyah B, Essa MM, Lee M, Chauhan V, Kaur K, Chauhan A. Muthaiyah B, et al. J Alzheimers Dis. 2014;42(4):1397-405. doi: 10.3233/JAD-140675. J Alzheimers Dis. 2014. PMID: 25024344
Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, can solubilize its fibrils, and has a protective effect against Aβ-induced oxidative stress and cellular death. ...These findings suggest that dietary supplementation with w …
Previous in vitro studies have shown that walnut extract can inhibit amyloid-β (Aβ) fibrillization, can solubilize its fibrils, and has a
Action of amyloid beta-protein on protein kinase C activity.
Chauhan A, Chauhan VP, Brockerhoff H, Wisniewski HM. Chauhan A, et al. Life Sci. 1991;49(21):1555-62. doi: 10.1016/0024-3205(91)90328-9. Life Sci. 1991. PMID: 1943460
The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar assay, and with calmodulin-depleted soluble brain proteins in a liposomal system. We report here that A
The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in …
Promotion of synthetic amyloid beta-peptide fibrillization by cell culture media and cessation of fibrillization by serum.
Wegiel J, Chauhan A, Wisniewski HM, Nowakowski J, Wang KC, Le Vine H 3rd. Wegiel J, et al. Neurosci Lett. 1996 Jun 28;211(3):151-4. doi: 10.1016/0304-3940(96)12739-7. Neurosci Lett. 1996. PMID: 8817563
This study indicates that amyloid beta fibrillogenesis in cell culture should be studied in serum-free media or in media with a low concentration of serum....
This study indicates that amyloid beta fibrillogenesis in cell culture should be studied in serum-free media or in media with a low c …
Effect of cerebrospinal fluid from normal and Alzheimer's patients with different apolipoprotein E phenotypes on in vitro aggregation of amyloid beta-protein.
Chauhan A, Pirttilä T, Mehta P, Chauhan VP, Wisniewski HM. Chauhan A, et al. J Neurol Sci. 1996 Sep 15;141(1-2):54-8. doi: 10.1016/0022-510x(96)00123-2. J Neurol Sci. 1996. PMID: 8880693
However, there was significantly less aggregation of A beta in presence of CSF from AD than that from non-demented controls. ...There was a positive correlation between CSF apoE concentrations and A beta aggregation; whereas age, CSF soluble A beta lev …
However, there was significantly less aggregation of A beta in presence of CSF from AD than that from non-demented controls. ...There …
Media from rhabdomyosarcoma and neuroblastoma cell cultures stimulate in vitro aggregation and fibrillization of amyloid beta-protein.
Chauhan A, Chauhan VP, Rubenstein R, Wegiel J, Wisniewski HM. Chauhan A, et al. Neurochem Res. 1997 Feb;22(2):227-32. doi: 10.1023/a:1027379926976. Neurochem Res. 1997. PMID: 9016850
In cultures supplemented with 10% FBS, the conditioned media from CRL 1598, HTB 82, CCL 218, and SY5Y cell cultures stimulated Abeta aggregation in a time-dependent manner as compared to that of control (serum-containing medium that had not been exposed to cells). ...
In cultures supplemented with 10% FBS, the conditioned media from CRL 1598, HTB 82, CCL 218, and SY5Y cell cultures stimulated Abeta aggrega …
Metal cations defibrillize the amyloid beta-protein fibrils.
Chauhan VP, Ray I, Chauhan A, Wegiel J, Wisniewski HM. Chauhan VP, et al. Neurochem Res. 1997 Jul;22(7):805-9. doi: 10.1023/a:1022079709085. Neurochem Res. 1997. PMID: 9232632
EM analysis in negative staining showed that A beta 1-40 fibrils in the absence of cations were organized in a fine network with a little or no amorphous material. ...Studies with A beta 1-42 showed that this peptide forms more dense network of fibrils …
EM analysis in negative staining showed that A beta 1-40 fibrils in the absence of cations were organized in a fine network wi …
Factors secreted by activated microglia and monocytes reduce amyloidogenesis in vascular smooth muscle cells.
Frackowiak J, Mazur-Kolecka B, Carroll RT, Chauhan A, Wisniewski HM. Frackowiak J, et al. Neuroreport. 1997 Jul 7;8(9-10):2259-63. doi: 10.1097/00001756-199707070-00033. Neuroreport. 1997. PMID: 9243622
Smooth muscle cells cultured from amyloid-beta-affected arteries accumulate amyloid-beta peptide A beta. We now show that accumulation of "A beta" deposits in this model can be significantly reduced by culture in conditioned media from microglia and monocytes. Reduc …
Smooth muscle cells cultured from amyloid-beta-affected arteries accumulate amyloid-beta peptide A beta. We now show that accumulatio …
Aggregation of amyloid beta-protein as function of age and apolipoprotein E in normal and Alzheimer's serum.
Chauhan A, Pirttilä T, Chauhan VP, Mehta P, Wisniewski HM. Chauhan A, et al. J Neurol Sci. 1998 Feb 5;154(2):159-63. doi: 10.1016/s0022-510x(97)00221-9. J Neurol Sci. 1998. PMID: 9562306
A beta 1-40 aggregation in presence of serum from the normal elderly group was significantly higher as compared to the normal young group (correlation coefficient between age and A beta aggregation=0.73). ...There was a positive correlation between serum apo
A beta 1-40 aggregation in presence of serum from the normal elderly group was significantly higher as compared to the normal young g
Binding of amyloid beta-protein to intracellular brain proteins in rat and human.
Ray I, Chauhan A, Wisniewski HM, Wegiel J, Kim KS, Chauhan VP. Ray I, et al. Neurochem Res. 1998 Oct;23(10):1277-82. doi: 10.1023/a:1020744216699. Neurochem Res. 1998. PMID: 9804283
Gelsolin inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils.
Ray I, Chauhan A, Wegiel J, Chauhan VP. Ray I, et al. Brain Res. 2000 Jan 24;853(2):344-51. doi: 10.1016/s0006-8993(99)02315-x. Brain Res. 2000. PMID: 10640633
We recently reported that gelsolin, a secretory protein, binds to Abeta, and that gelsolin/Abeta complex is present in the plasma [V.P.S. Chauhan, I. Ray, A. Chauhan, H.M. Wisniewski, Biochem. Biophys. Res. Commun. 258 (1999) 241-246.]. We now studied …
We recently reported that gelsolin, a secretory protein, binds to Abeta, and that gelsolin/Abeta complex is present in the plasma [V. …
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