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Gelsolin inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils.
Ray I, Chauhan A, Wegiel J, Chauhan VP. Ray I, et al. Among authors: chauhan a, chauhan vp. Brain Res. 2000 Jan 24;853(2):344-51. doi: 10.1016/s0006-8993(99)02315-x. Brain Res. 2000. PMID: 10640633
The mechanism that prevents soluble Abeta from fibrillization in biological fluids is not clear. We recently reported that gelsolin, a secretory protein, binds to Abeta, and that gelsolin/Abeta complex is present in the plasma [V.P.S. Chauhan, I. Ray, A. C
The mechanism that prevents soluble Abeta from fibrillization in biological fluids is not clear. We recently reported that gelsolin, a
1,826 results