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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 1
2006 2
2007 1
2008 1
2011 2
2012 3
2013 2
2014 2
2015 4
2016 4
2017 6
2018 2
2019 1
2020 3
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31 results
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Page 1
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Wiseman FK, et al. Among authors: chavez gutierrez l. Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Brain. 2018. PMID: 29945247 Free PMC article.
Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: chavez gutierrez l. Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004. Cell. 2017. PMID: 28753424 Free article.
Identification and characterization of Nanobodies targeting the EphA4 receptor.
Schoonaert L, Rué L, Roucourt B, Timmers M, Little S, Chávez-Gutiérrez L, Dewilde M, Joyce P, Curnock A, Weber P, Haustraete J, Hassanzadeh-Ghassabeh G, De Strooper B, Van Den Bosch L, Van Damme P, Lemmens R, Robberecht W. Schoonaert L, et al. Among authors: chavez gutierrez l. J Biol Chem. 2017 Jul 7;292(27):11452-11465. doi: 10.1074/jbc.M116.774141. Epub 2017 May 19. J Biol Chem. 2017. PMID: 28526745 Free PMC article.
Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.
Petit D, Hitzenberger M, Lismont S, Zoltowska KM, Ryan NS, Mercken M, Bischoff F, Zacharias M, Chávez-Gutiérrez L. Petit D, et al. Among authors: chavez gutierrez l. EMBO J. 2019 Jun 17;38(12):e101494. doi: 10.15252/embj.2019101494. Epub 2019 May 20. EMBO J. 2019. PMID: 31109937 Free PMC article.
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Ryan NS, Nicholas JM, Weston PSJ, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, Fox NC. Ryan NS, et al. Among authors: chavez gutierrez l. Lancet Neurol. 2016 Dec;15(13):1326-1335. doi: 10.1016/S1474-4422(16)30193-4. Epub 2016 Oct 21. Lancet Neurol. 2016. PMID: 27777022 Free article.
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.
Voytyuk I, De Strooper B, Chávez-Gutiérrez L. Voytyuk I, et al. Among authors: chavez gutierrez l. Biol Psychiatry. 2018 Feb 15;83(4):320-327. doi: 10.1016/j.biopsych.2017.08.001. Epub 2017 Aug 10. Biol Psychiatry. 2018. PMID: 28918941 Review.
Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins.
Veugelen S, Dewilde M, De Strooper B, Chávez-Gutiérrez L. Veugelen S, et al. Among authors: chavez gutierrez l. Methods Enzymol. 2017;584:59-97. doi: 10.1016/bs.mie.2016.10.029. Epub 2016 Dec 12. Methods Enzymol. 2017. PMID: 28065273 Review.
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, Munck S, Mizuno H, Annaert W. Escamilla-Ayala AA, et al. Among authors: chavez gutierrez l. Elife. 2020 Jul 7;9:e56679. doi: 10.7554/eLife.56679. Elife. 2020. PMID: 32631487 Free PMC article.
The dynamic conformational landscape of gamma-secretase.
Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. Elad N, et al. Among authors: chavez gutierrez l. J Cell Sci. 2015 Feb 1;128(3):589-98. doi: 10.1242/jcs.164384. J Cell Sci. 2015. PMID: 25501811 Free PMC article.
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: chavez gutierrez l. J Exp Med. 2015 Nov 16;212(12):2003-13. doi: 10.1084/jem.20150892. Epub 2015 Oct 19. J Exp Med. 2015. PMID: 26481686 Free PMC article.
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