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Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.
McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. McLaughlin JP, et al. Among authors: Chavkin TA, Chavkin C. Neuropsychopharmacology. 2006 Jun;31(6):1241-8. doi: 10.1038/sj.npp.1300872. Neuropsychopharmacology. 2006. PMID: 16123746 Free PMC article.
SDS-exposed mice conditioned with cocaine (15 mg/kg, s.c.) showed significant potentiation of place-preference for the drug-paired chamber over the responses of unstressed mice. ...
SDS-exposed mice conditioned with cocaine (15 mg/kg, s.c.) showed significant potentiation of place-preference for the drug-paired ch …
Kappa Antagonist JDTic in Phase 1 Clinical Trial.
Chavkin C, Martinez D. Chavkin C, et al. Neuropsychopharmacology. 2015 Aug;40(9):2057-8. doi: 10.1038/npp.2015.74. Neuropsychopharmacology. 2015. PMID: 26174493 Free PMC article. No abstract available.
Dynorphin, Dysphoria, and Dependence: the Stress of Addiction.
Chavkin C, Koob GF. Chavkin C, et al. Neuropsychopharmacology. 2016 Jan;41(1):373-4. doi: 10.1038/npp.2015.258. Neuropsychopharmacology. 2016. PMID: 26657953 Free PMC article. Review. No abstract available.
κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition.
Abraham AD, Fontaine HM, Song AJ, Andrews MM, Baird MA, Kieffer BL, Land BB, Chavkin C. Abraham AD, et al. Among authors: Chavkin C. Neuropsychopharmacology. 2018 Jan;43(2):362-372. doi: 10.1038/npp.2017.133. Epub 2017 Jun 26. Neuropsychopharmacology. 2018. PMID: 28649993 Free PMC article.
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