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Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Rising KA, et al. Among authors: chehade ka. ACS Chem Biol. 2015 Jul 17;10(7):1729-36. doi: 10.1021/acschembio.5b00145. Epub 2015 May 4. ACS Chem Biol. 2015. PMID: 25897591 Free PMC article.
Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.
Roberts MJ, Troutman JM, Chehade KA, Cha HC, Kao JP, Huang X, Zhan CG, Peterson YK, Subramanian T, Kamalakkannan S, Andres DA, Spielmann HP. Roberts MJ, et al. Among authors: chehade ka. Biochemistry. 2006 Dec 26;45(51):15862-72. doi: 10.1021/bi061704+. Epub 2006 Dec 6. Biochemistry. 2006. PMID: 17176109
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