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Elevated CNS inflammation in patients with preclinical Alzheimer's disease.
Monson NL, Ireland SJ, Ligocki AJ, Chen D, Rounds WH, Li M, Huebinger RM, Munro Cullum C, Greenberg BM, Stowe AM, Zhang R. Monson NL, et al. Among authors: chen d. J Cereb Blood Flow Metab. 2014 Jan;34(1):30-3. doi: 10.1038/jcbfm.2013.183. Epub 2013 Oct 23. J Cereb Blood Flow Metab. 2014. PMID: 24149932 Free PMC article.
Single dose of glycoengineered anti-CD19 antibody (MEDI551) disrupts experimental autoimmune encephalomyelitis by inhibiting pathogenic adaptive immune responses in the bone marrow and spinal cord while preserving peripheral regulatory mechanisms.
Chen D, Blazek M, Ireland S, Ortega S, Kong X, Meeuwissen A, Stowe A, Carter L, Wang Y, Herbst R, Monson NL. Chen D, et al. J Immunol. 2014 Nov 15;193(10):4823-32. doi: 10.4049/jimmunol.1401478. Epub 2014 Oct 3. J Immunol. 2014. PMID: 25281717 Free PMC article.
A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients.
Ligocki AJ, Rivas JR, Rounds WH, Guzman AA, Li M, Spadaro M, Lahey L, Chen D, Henson PM, Graves D, Greenberg BM, Frohman EM, Ward ES, Robinson W, Meinl E, White CL 3rd, Stowe AM, Monson NL. Ligocki AJ, et al. Among authors: chen d. ASN Neuro. 2015 Oct 21;7(5):1759091415609613. doi: 10.1177/1759091415609613. Print 2015 Sep-Oct. ASN Neuro. 2015. PMID: 26489686 Free PMC article.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B. Shi H, et al. Among authors: chen d. Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7. Nat Immunol. 2016. PMID: 26642356 Free PMC article.
Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.
Rivas JR, Ireland SJ, Chkheidze R, Rounds WH, Lim J, Johnson J, Ramirez DM, Ligocki AJ, Chen D, Guzman AA, Woodhall M, Wilson PC, Meffre E, White C 3rd, Greenberg BM, Waters P, Cowell LG, Stowe AM, Monson NL. Rivas JR, et al. Among authors: chen d. Acta Neuropathol. 2017 Jan;133(1):43-60. doi: 10.1007/s00401-016-1627-0. Epub 2016 Oct 11. Acta Neuropathol. 2017. PMID: 27730299 Free PMC article.
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