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Elements of cancer immunity and the cancer-immune set point.
Chen DS, Mellman I. Chen DS, et al. Nature. 2017 Jan 18;541(7637):321-330. doi: 10.1038/nature21349. Nature. 2017. PMID: 28102259 Review.
Cellular immunotherapy: antigen recognition is just the beginning.
Chen DS, Davis MM. Chen DS, et al. Springer Semin Immunopathol. 2005 Jun;27(1):119-27. doi: 10.1007/s00281-005-0200-z. Epub 2005 Apr 16. Springer Semin Immunopathol. 2005. PMID: 15834723 Review.
T cells use two directionally distinct pathways for cytokine secretion.
Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. Huse M, et al. Among authors: chen ds. Nat Immunol. 2006 Mar;7(3):247-55. doi: 10.1038/ni1304. Epub 2006 Jan 29. Nat Immunol. 2006. PMID: 16444260
Molecular pathways: next-generation immunotherapy--inhibiting programmed death-ligand 1 and programmed death-1.
Chen DS, Irving BA, Hodi FS. Chen DS, et al. Clin Cancer Res. 2012 Dec 15;18(24):6580-7. doi: 10.1158/1078-0432.CCR-12-1362. Epub 2012 Oct 19. Clin Cancer Res. 2012. PMID: 23087408
Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies.
Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, Kaminker JS, Jurinka SS, Kolumam G, Chung AS, Jubb A, Modrusan Z, Ozawa T, James CD, Phillips H, Haley B, Tam RN, Clermont AC, Cheng JH, Yang SX, Swain SM, Chen D, Scherer SJ, Koeppen H, Yeh RF, Yue P, Stephan JP, Hegde P, Ferrara N, Singh M, Bais C. Brauer MJ, et al. Among authors: chen d. Clin Cancer Res. 2013 Jul 1;19(13):3681-92. doi: 10.1158/1078-0432.CCR-12-3635. Epub 2013 May 17. Clin Cancer Res. 2013. PMID: 23685835
Oncology meets immunology: the cancer-immunity cycle.
Chen DS, Mellman I. Chen DS, et al. Immunity. 2013 Jul 25;39(1):1-10. doi: 10.1016/j.immuni.2013.07.012. Immunity. 2013. PMID: 23890059 Review.
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.
Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, Bellmunt J, Burris HA, Petrylak DP, Teng SL, Shen X, Boyd Z, Hegde PS, Chen DS, Vogelzang NJ. Powles T, et al. Among authors: chen ds. Nature. 2014 Nov 27;515(7528):558-62. doi: 10.1038/nature13904. Nature. 2014. PMID: 25428503 Clinical Trial.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS. Herbst RS, et al. Among authors: chen ds. Nature. 2014 Nov 27;515(7528):563-7. doi: 10.1038/nature14011. Nature. 2014. PMID: 25428504 Free PMC article. Clinical Trial.
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial.
Fehrenbacher L, Spira A, Ballinger M, Kowanetz M, Vansteenkiste J, Mazieres J, Park K, Smith D, Artal-Cortes A, Lewanski C, Braiteh F, Waterkamp D, He P, Zou W, Chen DS, Yi J, Sandler A, Rittmeyer A; POPLAR Study Group. Fehrenbacher L, et al. Among authors: chen ds. Lancet. 2016 Apr 30;387(10030):1837-46. doi: 10.1016/S0140-6736(16)00587-0. Epub 2016 Mar 10. Lancet. 2016. PMID: 26970723 Clinical Trial.
De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.
Mellman I, Hubbard-Lucey VM, Tontonoz MJ, Kalos MD, Chen DS, Allison JP, Drake CG, Levitsky H, Lonberg N, van der Burg SH, Fearon DT, Wherry EJ, Lowy I, Vonderheide RH, Hwu P. Mellman I, et al. Among authors: chen ds. Cancer Immunol Res. 2016 Apr;4(4):279-88. doi: 10.1158/2326-6066.CIR-16-0045. Cancer Immunol Res. 2016. PMID: 27036972 Review.
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