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Physiological functions of mitochondrial fusion.
Chen H, Chan DC. Chen H, et al. Ann N Y Acad Sci. 2010 Jul;1201:21-5. doi: 10.1111/j.1749-6632.2010.05615.x. Ann N Y Acad Sci. 2010. PMID: 20649534 Review.
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
Toyama EQ, Herzig S, Courchet J, Lewis TL Jr, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. Toyama EQ, et al. Among authors: chen h. Science. 2016 Jan 15;351(6270):275-281. doi: 10.1126/science.aab4138. Science. 2016. PMID: 26816379 Free PMC article.
Structural basis of mitochondrial tethering by mitofusin complexes.
Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC. Koshiba T, et al. Among authors: chen h. Science. 2004 Aug 6;305(5685):858-62. doi: 10.1126/science.1099793. Science. 2004. PMID: 15297672
Disruption of fusion results in mitochondrial heterogeneity and dysfunction.
Chen H, Chomyn A, Chan DC. Chen H, et al. J Biol Chem. 2005 Jul 15;280(28):26185-92. doi: 10.1074/jbc.M503062200. Epub 2005 May 17. J Biol Chem. 2005. PMID: 15899901
Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington's Disease Mouse Model.
Cha MY, Chen H, Chan D. Cha MY, et al. Among authors: chen h. PLoS Curr. 2018 Jul 26;10:ecurrents.hd.a4e15b80c4915c828d39754942c6631f. doi: 10.1371/currents.hd.a4e15b80c4915c828d39754942c6631f. PLoS Curr. 2018. PMID: 30279997 Free PMC article.
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.
Chen H, Chan DC. Chen H, et al. Cell Metab. 2017 Jul 5;26(1):39-48. doi: 10.1016/j.cmet.2017.05.016. Epub 2017 Jun 22. Cell Metab. 2017. PMID: 28648983 Free PMC article. Review.
Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
Chen H, Ren S, Clish C, Jain M, Mootha V, McCaffery JM, Chan DC. Chen H, et al. J Cell Biol. 2015 Nov 23;211(4):795-805. doi: 10.1083/jcb.201507035. J Cell Biol. 2015. PMID: 26598616 Free PMC article.
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Losón OC, Song Z, Chen H, Chan DC. Losón OC, et al. Among authors: chen h. Mol Biol Cell. 2013 Mar;24(5):659-67. doi: 10.1091/mbc.E12-10-0721. Epub 2013 Jan 2. Mol Biol Cell. 2013. PMID: 23283981 Free PMC article.
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Chen H, et al. Cell. 2010 Apr 16;141(2):280-9. doi: 10.1016/j.cell.2010.02.026. Cell. 2010. PMID: 20403324 Free PMC article.
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.
Chen H, Chan DC. Chen H, et al. Hum Mol Genet. 2009 Oct 15;18(R2):R169-76. doi: 10.1093/hmg/ddp326. Hum Mol Genet. 2009. PMID: 19808793 Free PMC article. Review.
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