Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c.
Oncotarget. 2016 Dec 13;7(50):82770-82782. doi: 10.18632/oncotarget.13165.
Free PMC article.
We investigated whether H. pylori infection could promote gastric cancer by regulating lncRNAs expression. Differentially expressed lncRNAs between H. pylori positive and negative tissues were identified by microarray and validated by qRT-PCR. ...We identified an lncRNA-AF147447 decreased expressed by H. pylori infection, which can inhibit GC proliferation and invasion in vitro and in vivo, act as a tumor suppressor in the development of H. pylori induced GC. ...
We investigated whether H. pylori infection could promote gastric cancer by regulating lncRNAs expression. Differentially expressed l …