Chen J - Search Results

1

Bleomycins: towards better therapeutics.

Chen J, Stubbe J. Chen J, et al. Nat Rev Cancer. 2005 Feb;5(2):102-12. doi: 10.1038/nrc1547. Nat Rev Cancer. 2005. PMID: 15685195 Review.

2

GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin.

Chen B, Zhou X, Taghizadeh K, Chen J, Stubbe J, Dedon PC. Chen B, et al. Among authors: chen j. Chem Res Toxicol. 2007 Nov;20(11):1701-8. doi: 10.1021/tx700164y. Epub 2007 Oct 19. Chem Res Toxicol. 2007. PMID: 17944541 Free PMC article.

3

Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage.

Chen J, Ghorai MK, Kenney G, Stubbe J. Chen J, et al. Nucleic Acids Res. 2008 Jun;36(11):3781-90. doi: 10.1093/nar/gkn302. Epub 2008 May 20. Nucleic Acids Res. 2008. PMID: 18492718 Free PMC article.

4

Synthesis and characterization of oligonucleotides containing a 4'-keto abasic site.

Chen J, Stubbe J. Chen J, et al. Biochemistry. 2004 May 11;43(18):5278-86. doi: 10.1021/bi0495376. Biochemistry. 2004. PMID: 15122893

5

Bleomycins: new methods will allow reinvestigation of old issues.

Chen J, Stubbe J. Chen J, et al. Curr Opin Chem Biol. 2004 Apr;8(2):175-81. doi: 10.1016/j.cbpa.2004.02.008. Curr Opin Chem Biol. 2004. PMID: 15062779 Review.

6

Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation.

Wu W, Vanderwall DE, Turner CJ, Hoehn S, Chen J, Kozarich JW, Stubbe J. Wu W, et al. Among authors: chen j. Nucleic Acids Res. 2002 Nov 15;30(22):4881-91. doi: 10.1093/nar/gkf608. Nucleic Acids Res. 2002. PMID: 12433991 Free PMC article.

7

Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion.

Junker HD, Hoehn ST, Bunt RC, Marathius V, Chen J, Turner CJ, Stubbe J. Junker HD, et al. Among authors: chen j. Nucleic Acids Res. 2002 Dec 15;30(24):5497-508. doi: 10.1093/nar/gkf681. Nucleic Acids Res. 2002. PMID: 12490718 Free PMC article.

8

Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites.

Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. Chen J, et al. Biochemistry. 2007 Mar 20;46(11):3096-107. doi: 10.1021/bi6024269. Epub 2007 Feb 27. Biochemistry. 2007. PMID: 17323932

9

DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics.

Chen J, Dupradeau FY, Case DA, Turner CJ, Stubbe J. Chen J, et al. Nucleic Acids Res. 2008 Jan;36(1):253-62. doi: 10.1093/nar/gkm622. Epub 2007 Nov 19. Nucleic Acids Res. 2008. PMID: 18025040 Free PMC article.

Studies on a duplex DNA with an A opposite the abasic site in the same sequence has recently been reported [Chen,J., Dupradeau,F.-Y., Case,D.A., Turner,C.J. and Stubbe,J. (2007) Nuclear magnetic resonance structural studies and molecular modeling of du …

Studies on a duplex DNA with an A opposite the abasic site in the same sequence has recently been reported [Chen,J., Dupradeau …

10

Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template.

Tsai CH, Chen J, Szostak JW. Tsai CH, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14598-603. doi: 10.1073/pnas.0704211104. Epub 2007 Sep 4. Proc Natl Acad Sci U S A. 2007. PMID: 17785419 Free PMC article.

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