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Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Xu H, et al. Among authors: chen j. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17. Cell. 2019. PMID: 30661758 Free article.
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Liu C, Reese R, Vu S, Rougé L, Shields SD, Kakiuchi-Kiyota S, Chen H, Johnson K, Shi YP, Chernov-Rogan T, Greiner DMZ, Kohli PB, Hackos D, Brillantes B, Tam C, Li T, Wang J, Safina B, Magnuson S, Volgraf M, Payandeh J, Zheng J, Rohou A, Chen J. Liu C, et al. Among authors: chen j, chen h. Neuron. 2021 Jan 20;109(2):273-284.e4. doi: 10.1016/j.neuron.2020.10.014. Epub 2020 Nov 4. Neuron. 2021. PMID: 33152265 Free PMC article.
TRPA1 as a drug target--promise and challenges.
Chen J, Hackos DH. Chen J, et al. Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):451-63. doi: 10.1007/s00210-015-1088-3. Epub 2015 Feb 3. Naunyn Schmiedebergs Arch Pharmacol. 2015. PMID: 25640188 Free PMC article. Review.
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.
Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J. Chernov-Rogan T, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. doi: 10.1073/pnas.1713701115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311306 Free PMC article.
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Xu H, et al. Among authors: chen j. Cell. 2019 Feb 21;176(5):1238-1239. doi: 10.1016/j.cell.2019.01.047. Cell. 2019. PMID: 30794776 Free article. No abstract available.
TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism.
Chernov-Rogan T, Gianti E, Liu C, Villemure E, Cridland AP, Hu X, Ballini E, Lange W, Deisemann H, Li T, Ward SI, Hackos DH, Magnuson S, Safina B, Klein ML, Volgraf M, Carnevale V, Chen J. Chernov-Rogan T, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):26008-26019. doi: 10.1073/pnas.1913929116. Epub 2019 Dec 3. Proc Natl Acad Sci U S A. 2019. PMID: 31796582 Free PMC article.
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