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A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
A thermostable Cas9 with increased lifetime in human plasma.
Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA. Harrington LB, et al. Nat Commun. 2017 Nov 10;8(1):1424. doi: 10.1038/s41467-017-01408-4. Nat Commun. 2017. PMID: 29127284 Free PMC article.
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Chen JS, et al. Nature. 2017 Oct 19;550(7676):407-410. doi: 10.1038/nature24268. Epub 2017 Sep 20. Nature. 2017. PMID: 28931002 Free PMC article.
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Jiang F, et al. Science. 2016 Feb 19;351(6275):867-71. doi: 10.1126/science.aad8282. Epub 2016 Jan 14. Science. 2016. PMID: 26841432 Free PMC article.
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Harrington LB, et al. Science. 2018 Nov 16;362(6416):839-842. doi: 10.1126/science.aav4294. Epub 2018 Oct 18. Science. 2018. PMID: 30337455 Free PMC article.
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