Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

48,557 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features.
Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Liew OW, Zhu W, Puah CM, Shen X, Jiang H. Chen L, et al. Among authors: Chen G. Bioorg Med Chem. 2006 Dec 15;14(24):8295-306. doi: 10.1016/j.bmc.2006.09.014. Epub 2006 Oct 12. Bioorg Med Chem. 2006. PMID: 17046271 Free PMC article.
Small molecules from natural sources, targeting signaling pathways in diabetes.
Liu Q, Chen L, Hu L, Guo Y, Shen X. Liu Q, et al. Among authors: Chen L. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):854-65. doi: 10.1016/j.bbagrm.2010.06.004. Epub 2010 Jun 23. Biochim Biophys Acta. 2010. PMID: 20601278 Review.
Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling.
Han C, Zhang J, Chen L, Chen K, Shen X, Jiang H. Han C, et al. Among authors: Chen L, Chen K. Bioorg Med Chem. 2007 Jan 15;15(2):656-62. doi: 10.1016/j.bmc.2006.10.058. Epub 2006 Nov 1. Bioorg Med Chem. 2007. PMID: 17098431
The molecular modeling and docking of two inhibitors with HpSK reveals that the active site of HpSK is rather roomy and deep, forming an L-shape channel on the surface of the protein, and compound 1 prefers the corner area of L-shape channel, while compound 2 binds the short arm of the channel of SK in the binding interactions. ...
The molecular modeling and docking of two inhibitors with HpSK reveals that the active site of HpSK is rather roomy and deep, forming an …
(+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice.
Zhang Y, Zhang H, Yao XG, Shen H, Chen J, Li C, Chen L, Zheng M, Ye J, Hu L, Shen X, Jiang H. Zhang Y, et al. Among authors: Chen J, Chen L. PLoS One. 2012;7(2):e31811. doi: 10.1371/journal.pone.0031811. Epub 2012 Feb 27. PLoS One. 2012. PMID: 22384078 Free PMC article.
Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori.
Kong Y, Wu D, Bai H, Han C, Chen J, Chen L, Hu L, Jiang H, Shen X. Kong Y, et al. Among authors: Chen J, Chen L. J Biochem. 2008 Jan;143(1):59-68. doi: 10.1093/jb/mvm194. Epub 2007 Nov 1. J Biochem. 2008. PMID: 17981822
Cystathionine gamma-synthase (CGS) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human. ...Enzymatic study of HpCGS indicated that the K(m) and k(cat)/K(m) values against the substrate O-succinyl-l-homoserine (l-OSHS) were 3.02 mM and 98.7 M(-)(1)s(-)(1), respectively. ...
Cystathionine gamma-synthase (CGS) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homo …
Molecular determinants of magnolol targeting both RXRα and PPARγ.
Zhang H, Xu X, Chen L, Chen J, Hu L, Jiang H, Shen X. Zhang H, et al. Among authors: Chen L, Chen J. PLoS One. 2011;6(11):e28253. doi: 10.1371/journal.pone.0028253. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140563 Free PMC article.
Structural analyses reveal that magnolol adopts its two 5-allyl-2-hydroxyphenyl moieties occupying the acidic and hydrophobic cavities of RXRα L-shaped ligand-binding pocket, respectively. ...
Structural analyses reveal that magnolol adopts its two 5-allyl-2-hydroxyphenyl moieties occupying the acidic and hydrophobic cavities of RX …
48,557 results
Jump to page
Feedback