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Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D. Geng J, et al. Among authors: chen l, chen q. Nat Immunol. 2015 Nov;16(11):1142-52. doi: 10.1038/ni.3268. Epub 2015 Sep 28. Nat Immunol. 2015. PMID: 26414765 Free PMC article.
Hippo pathway in intestinal homeostasis and tumorigenesis.
Chen L, Qin F, Deng X, Avruch J, Zhou D. Chen L, et al. Protein Cell. 2012 Apr;3(4):305-10. doi: 10.1007/s13238-012-2913-9. Epub 2012 Apr 10. Protein Cell. 2012. PMID: 22492181 Free PMC article. Review.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D. Wu H, et al. Among authors: chen l. Cell Rep. 2013 May 30;3(5):1663-77. doi: 10.1016/j.celrep.2013.04.020. Epub 2013 May 16. Cell Rep. 2013. PMID: 23684612 Free PMC article.
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.
Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han J. Wu J, et al. Among authors: chen l, chen w. Cell Res. 2013 Aug;23(8):994-1006. doi: 10.1038/cr.2013.91. Epub 2013 Jul 9. Cell Res. 2013. PMID: 23835476 Free PMC article.
Mst1 and Mst2 kinases: regulations and diseases.
Qin F, Tian J, Zhou D, Chen L. Qin F, et al. Among authors: chen l. Cell Biosci. 2013 Aug 28;3(1):31. doi: 10.1186/2045-3701-3-31. Cell Biosci. 2013. PMID: 23985272 Free PMC article.
The Hippo signaling pathway in liver regeneration and tumorigenesis.
Hong L, Cai Y, Jiang M, Zhou D, Chen L. Hong L, et al. Among authors: chen l. Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):46-52. doi: 10.1093/abbs/gmu106. Epub 2014 Dec 4. Acta Biochim Biophys Sin (Shanghai). 2015. PMID: 25476204 Free article. Review.
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D. Wu H, et al. Among authors: chen l, chen q. Nat Commun. 2015 Feb 19;6:6239. doi: 10.1038/ncomms7239. Nat Commun. 2015. PMID: 25695629 Free article.
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D. Fan F, et al. Among authors: chen l, chen q. Sci Transl Med. 2016 Aug 17;8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304. Sci Transl Med. 2016. PMID: 27535619
Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors.
Jiang J, Gui F, He Z, Li L, Li Y, Li S, Wu X, Deng Z, Sun X, Huang X, Huang W, Han S, Zhang T, Wang Z, Jiao B, Song S, Wang H, Chen L, Zhou D, Liu Q, Ren R, Zhang J, Deng X. Jiang J, et al. Among authors: chen l. Cancer Res. 2017 Jan 1;77(1):175-186. doi: 10.1158/0008-5472.CAN-16-1038. Epub 2016 Oct 10. Cancer Res. 2017. PMID: 27758886
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