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The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.
Arutyunova E, Belovodskiy A, Chen P, Khan MB, Joyce M, Saffran H, Lu J, Turner Z, Bai B, Lamer T, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. Arutyunova E, et al. Among authors: chen p. ACS Bio Med Chem Au. 2023 Nov 15;3(6):528-541. doi: 10.1021/acsbiomedchemau.3c00039. eCollection 2023 Dec 20. ACS Bio Med Chem Au. 2023. PMID: 38144257 Free PMC article.
Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design.
Fischer C, Lu J, van Belkum MJ, Demmon S, Chen P, Wang C, Van Oers TJ, Lamer T, Lemieux MJ, Vederas JC. Fischer C, et al. Among authors: chen p. RSC Med Chem. 2025 Aug 15;16(10):5032-5040. doi: 10.1039/d5md00356c. eCollection 2025 Oct 15. RSC Med Chem. 2025. PMID: 40823489 Free PMC article.
Antibiotic Use Linked to Worse Outcomes in Gastrointestinal and Liver Cancer Patients on Immune Checkpoint Inhibitors: A Meta-Analysis.
Rezaee-Zavareh MS, Karimi-Sari H, Roudsari PP, Khattab O, Attia AM, Danpanichkul P, Hwang SY, Liu JS, Yalda T, Chen PJ, Gong J, Ferrone CR, Rich NE, Parikh ND, Pinato DJ, Singal AG, Yang JD. Rezaee-Zavareh MS, et al. Among authors: chen pj. Am J Gastroenterol. 2026 Feb 12. doi: 10.14309/ajg.0000000000003956. Online ahead of print. Am J Gastroenterol. 2026. PMID: 41677135
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