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Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting.
Chen Q, Osada K, Ge Z, Uchida S, Tockary TA, Dirisala A, Matsui A, Toh K, Takeda KM, Liu X, Nomoto T, Ishii T, Oba M, Matsumoto Y, Kataoka K. Chen Q, et al. Biomaterials. 2017 Jan;113:253-265. doi: 10.1016/j.biomaterials.2016.10.042. Epub 2016 Oct 28. Biomaterials. 2017. PMID: 27835820
Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity.
Uchida S, Itaka K, Chen Q, Osada K, Miyata K, Ishii T, Harada-Shiba M, Kataoka K. Uchida S, et al. Among authors: chen q. J Control Release. 2011 Oct 30;155(2):296-302. doi: 10.1016/j.jconrel.2011.04.026. Epub 2011 May 5. J Control Release. 2011. PMID: 21571018
Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.
Dirisala A, Osada K, Chen Q, Tockary TA, Machitani K, Osawa S, Liu X, Ishii T, Miyata K, Oba M, Uchida S, Itaka K, Kataoka K. Dirisala A, et al. Among authors: chen q. Biomaterials. 2014 Jul;35(20):5359-5368. doi: 10.1016/j.biomaterials.2014.03.037. Epub 2014 Apr 8. Biomaterials. 2014. PMID: 24720877
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