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A novel sulindac derivative protects against oxidative damage by a cyclooxygenase-independent mechanism.
Allani SK, Rayala R, Rivera O, Prentice HM, Chen X, Ramírez-Alcántara V, Canzoneri J, Menzie-Suderam J, Huang X, Georgescu C, Wren JD, Piazza GA, Weissbach H. Allani SK, et al. Among authors: chen x. J Pharmacol Exp Ther. 2022 Jun 9;382(2):79-87. doi: 10.1124/jpet.122.001086. Online ahead of print. J Pharmacol Exp Ther. 2022. PMID: 35680377 Free PMC article.
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. Whitt JD, et al. Among authors: chen x. Cancer Prev Res (Phila). 2012 Jun;5(6):822-33. doi: 10.1158/1940-6207.CAPR-11-0559. Epub 2012 May 3. Cancer Prev Res (Phila). 2012. PMID: 22556201 Free PMC article.
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.
Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA. Zhu B, et al. Among authors: chen x. Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050202 Free PMC article.
Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.
Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X, Keeton AB, Ramirez-Alcantara V, Maxuitenko Y, Piazza GA, De Laurenzi V, Sala G, Falasca M. Adamska A, et al. Among authors: chen x. J Exp Clin Cancer Res. 2019 Aug 5;38(1):312. doi: 10.1186/s13046-019-1308-7. J Exp Clin Cancer Res. 2019. PMID: 31378204 Free PMC article.
Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS.
Ward AB, Keeton AB, Chen X, Mattox TE, Coley AB, Maxuitenko YY, Buchsbaum DJ, Randall TD, Zhou G, Piazza GA. Ward AB, et al. Among authors: chen x. MedComm (2020). 2020 Sep;1(2):121-128. doi: 10.1002/mco2.10. Epub 2020 Jun 25. MedComm (2020). 2020. PMID: 33073260 Free PMC article.
Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin.
Lee KJ, Chang WL, Chen X, Valiyaveettil J, Ramirez-Alcantara V, Gavin E, Musiyenko A, Madeira da Silva L, Annamdevula NS, Leavesley SJ, Ward A, Mattox T, Lindsey AS, Andrews J, Zhu B, Wood C, Neese A, Nguyen A, Berry K, Maxuitenko Y, Moyer MP, Nurmemmedov E, Gorman G, Coward L, Zhou G, Keeton AB, Cooper HS, Clapper ML, Piazza GA. Lee KJ, et al. Among authors: chen x. Cancer Prev Res (Phila). 2021 Nov;14(11):995-1008. doi: 10.1158/1940-6207.CAPR-21-0208. Epub 2021 Sep 28. Cancer Prev Res (Phila). 2021. PMID: 34584001 Free PMC article.
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