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Functional insights from structural genomics.
Forouhar F, Kuzin A, Seetharaman J, Lee I, Zhou W, Abashidze M, Chen Y, Yong W, Janjua H, Fang Y, Wang D, Cunningham K, Xiao R, Acton TB, Pichersky E, Klessig DF, Porter CW, Montelione GT, Tong L. Forouhar F, et al. Among authors: chen y. J Struct Funct Genomics. 2007 Sep;8(2-3):37-44. doi: 10.1007/s10969-007-9018-3. Epub 2007 Jun 23. J Struct Funct Genomics. 2007. PMID: 17588214
Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.
Forouhar F, Yang Y, Kumar D, Chen Y, Fridman E, Park SW, Chiang Y, Acton TB, Montelione GT, Pichersky E, Klessig DF, Tong L. Forouhar F, et al. Among authors: chen y. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1773-8. doi: 10.1073/pnas.0409227102. Epub 2005 Jan 24. Proc Natl Acad Sci U S A. 2005. PMID: 15668381 Free PMC article.
Molecular insights into the biosynthesis of the F420 coenzyme.
Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L. Forouhar F, et al. Among authors: chen y. J Biol Chem. 2008 Apr 25;283(17):11832-40. doi: 10.1074/jbc.M710352200. Epub 2008 Feb 5. J Biol Chem. 2008. PMID: 18252724 Free PMC article.
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data.
Price WN 2nd, Chen Y, Handelman SK, Neely H, Manor P, Karlin R, Nair R, Liu J, Baran M, Everett J, Tong SN, Forouhar F, Swaminathan SS, Acton T, Xiao R, Luft JR, Lauricella A, DeTitta GT, Rost B, Montelione GT, Hunt JF. Price WN 2nd, et al. Among authors: chen y. Nat Biotechnol. 2009 Jan;27(1):51-7. doi: 10.1038/nbt.1514. Nat Biotechnol. 2009. PMID: 19079241 Free PMC article.
Comparisons of NMR spectral quality and success in crystallization demonstrate that NMR and X-ray crystallography are complementary methods for small protein structure determination.
Snyder DA, Chen Y, Denissova NG, Acton T, Aramini JM, Ciano M, Karlin R, Liu J, Manor P, Rajan PA, Rossi P, Swapna GV, Xiao R, Rost B, Hunt J, Montelione GT. Snyder DA, et al. Among authors: chen y. J Am Chem Soc. 2005 Nov 30;127(47):16505-11. doi: 10.1021/ja053564h. J Am Chem Soc. 2005. PMID: 16305237
UNC119 is required for G protein trafficking in sensory neurons.
Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W. Zhang H, et al. Among authors: chen y. Nat Neurosci. 2011 Jun 5;14(7):874-80. doi: 10.1038/nn.2835. Nat Neurosci. 2011. PMID: 21642972 Free PMC article.
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice.
Chandía-Cristi A, Gutiérrez DA, Dulcey AE, Lara M, Vargas L, Lin YH, Jimenez-Muñoz P, Larenas G, Xu X, Wang A, Owens A, Dextras C, Chen Y, Pinto C, Marín T, Almarza-Salazar H, Acevedo K, Cancino GI, Hu X, Rojas P, Ferrer M, Southall N, Henderson MJ, Zanlungo S, Marugan JJ, Álvarez R A. Chandía-Cristi A, et al. Among authors: chen y. Cell Rep. 2024 Apr 23;43(5):114144. doi: 10.1016/j.celrep.2024.114144. Online ahead of print. Cell Rep. 2024. PMID: 38656874
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