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Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons.
Huang CY, Chen YL, Li AH, Lu JC, Wang HL. Huang CY, et al. J Neuroinflammation. 2014 Jan 10;11:7. doi: 10.1186/1742-2094-11-7. J Neuroinflammation. 2014. PMID: 24405660 Free PMC article.
Polyglutamine-expanded ataxin-7 decreases nuclear translocation of NF-kappaB p65 and impairs NF-kappaB activity by inhibiting proteasome activity of cerebellar neurons.
Wang HL, He CY, Chou AH, Yeh TH, Chen YL, Li AH. Wang HL, et al. Cell Signal. 2007 Mar;19(3):573-81. doi: 10.1016/j.cellsig.2006.08.006. Epub 2006 Aug 23. Cell Signal. 2007. PMID: 17005371
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Chou AH, Lin AC, Hong KY, Hu SH, Chen YL, Chen JY, Wang HL. Chou AH, et al. Neurochem Int. 2011 Feb;58(2):145-52. doi: 10.1016/j.neuint.2010.11.005. Epub 2010 Nov 16. Neurochem Int. 2011. PMID: 21092747
CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons.
Kao DJ, Li AH, Chen JC, Luo RS, Chen YL, Lu JC, Wang HL. Kao DJ, et al. J Neuroinflammation. 2012 Aug 8;9:189. doi: 10.1186/1742-2094-9-189. J Neuroinflammation. 2012. PMID: 22870919 Free PMC article.
(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse.
Chou JS, Chen CY, Chen YL, Weng YH, Yeh TH, Lu CS, Chang YM, Wang HL. Chou JS, et al. Neurobiol Dis. 2014 Aug;68:190-9. doi: 10.1016/j.nbd.2014.04.021. Epub 2014 May 14. Neurobiol Dis. 2014. PMID: 24830390
Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation.
Chou AH, Chen YL, Hu SH, Chang YM, Wang HL. Chou AH, et al. Brain Res. 2014 Oct 2;1583:220-9. doi: 10.1016/j.brainres.2014.08.019. Epub 2014 Aug 17. Brain Res. 2014. PMID: 25139423
(R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model.
Weng YH, Chen CY, Lin KJ, Chen YL, Yeh TH, Hsiao IT, Chen IJ, Lu CS, Wang HL. Weng YH, et al. Exp Neurol. 2016 Jan;275 Pt 1:104-15. doi: 10.1016/j.expneurol.2015.09.001. Epub 2015 Sep 10. Exp Neurol. 2016. PMID: 26363496
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL. Chiu CC, et al. Mol Neurobiol. 2019 Jun;56(6):3835-3853. doi: 10.1007/s12035-018-1118-5. Epub 2018 Aug 8. Mol Neurobiol. 2019. PMID: 30088174
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