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Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria.
Di Trani JM, Yu J, Courbon GM, Lobez Rodriguez AP, Cheung CY, Liang Y, Coupland CE, Bueler SA, Cook GM, Brzezinski P, Rubinstein JL. Di Trani JM, et al. Among authors: cheung cy. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2423761122. doi: 10.1073/pnas.2423761122. Epub 2025 Feb 19. Proc Natl Acad Sci U S A. 2025. PMID: 39969994 Free PMC article.
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.
Wang X, Jowsey WJ, Cheung CY, Smart CJ, Klaus HR, Seeto NE, Waller NJ, Chrisp MT, Peterson AL, Ofori-Anyinam B, Strong E, Nijagal B, West NP, Yang JH, Fineran PC, Cook GM, Jackson SA, McNeil MB. Wang X, et al. Among authors: cheung cy. Nat Commun. 2024 Nov 13;15(1):9791. doi: 10.1038/s41467-024-54072-w. Nat Commun. 2024. PMID: 39537607 Free PMC article.
Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.
Tran W, Kusay AS, Hawkins PME, Cheung CY, Nagalingam G, Pujari V, Ford DJ, Stoye A, Ochoa JL, Audette RE, Hortle E, Oehlers SH, Charman SA, Linington RG, Rubin EJ, Dowson CG, Roper DI, Crick DC, Balle T, Cook GM, Britton WJ, Payne RJ. Tran W, et al. Among authors: cheung cy. J Med Chem. 2021 Dec 9;64(23):17326-17345. doi: 10.1021/acs.jmedchem.1c01407. Epub 2021 Nov 30. J Med Chem. 2021. PMID: 34845906
36 results