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An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE. Holland WL, et al. Among authors: cheng cc. Cell Metab. 2013 May 7;17(5):790-7. doi: 10.1016/j.cmet.2013.03.019. Cell Metab. 2013. PMID: 23663742 Free PMC article.
FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans.
Samms RJ, Lewis JE, Norton L, Stephens FB, Gaffney CJ, Butterfield T, Smith DP, Cheng CC, Perfield JW 2nd, Adams AC, Ebling FJP, Tsintzas K. Samms RJ, et al. Among authors: cheng cc. J Clin Endocrinol Metab. 2017 Oct 1;102(10):3806-3813. doi: 10.1210/jc.2017-01257. J Clin Endocrinol Metab. 2017. PMID: 28938434 Free PMC article. Clinical Trial.
FGF21 requires βklotho to act in vivo.
Adams AC, Cheng CC, Coskun T, Kharitonenkov A. Adams AC, et al. Among authors: cheng cc. PLoS One. 2012;7(11):e49977. doi: 10.1371/journal.pone.0049977. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209629 Free PMC article.
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.
Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC. Samms RJ, et al. Among authors: cheng cc. Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5. Cell Rep. 2015. PMID: 25956583 Free article.
FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes.
Samms RJ, Cheng CC, Fourcaudot M, Heikkinen S, Khattab A, Adams J, Cersosimo E, Triplitt C, Puckett C, Tsintzas K, Adams AC, Abdul-Ghani MA, DeFronzo RA, Norton L. Samms RJ, et al. Among authors: cheng cc. Am J Physiol Endocrinol Metab. 2022 Aug 1;323(2):E123-E132. doi: 10.1152/ajpendo.00050.2022. Epub 2022 Jun 20. Am J Physiol Endocrinol Metab. 2022. PMID: 35723225 Free PMC article. Clinical Trial.
979 results