Cheng J - Search Results

1

Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis.

Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Duan W, et al. Among authors: cheng j. Eur J Med Chem. 2021 Dec 15;226:113878. doi: 10.1016/j.ejmech.2021.113878. Epub 2021 Oct 5. Eur J Med Chem. 2021. PMID: 34634742

2

Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents.

Cheng J, Qin J, Guo S, Qiu H, Zhong Y. Cheng J, et al. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4768-4772. doi: 10.1016/j.bmcl.2014.06.080. Epub 2014 Jul 5. Bioorg Med Chem Lett. 2014. PMID: 25182565

3

Design and Discovery of Functionally Selective Serotonin 2C (5-HT_2C) Receptor Agonists.

Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Nov 10;59(21):9866-9880. doi: 10.1021/acs.jmedchem.6b01194. Epub 2016 Oct 25. J Med Chem. 2016. PMID: 27726356

4

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ. Peng Y, et al. Among authors: cheng j. Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1. Cell. 2018. PMID: 29398112 Free PMC article.

5

Identification of natural products as novel ligands for the human 5-HT_2C receptor.

Peng Y, Zhao S, Wu Y, Cao H, Xu Y, Liu X, Shui W, Cheng J, Zhao S, Shen L, Ma J, Quinn RJ, Stevens RC, Zhong G, Liu ZJ. Peng Y, et al. Among authors: cheng j. Biophys Rep. 2018;4(1):50-61. doi: 10.1007/s41048-018-0047-1. Epub 2018 Mar 9. Biophys Rep. 2018. PMID: 29577069 Free PMC article.

6

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Tan L, Yan W, McCorvy JD, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2018 Nov 21;61(22):9841-9878. doi: 10.1021/acs.jmedchem.8b00435. Epub 2018 Jul 10. J Med Chem. 2018. PMID: 29939744 Review.

7

Optimization of P2Y₁₂ Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.

Kong D, Xue T, Guo B, Cheng J, Liu S, Wei J, Lu Z, Liu H, Gong G, Lan T, Hu W, Yang Y. Kong D, et al. Among authors: cheng j. J Med Chem. 2019 Mar 28;62(6):3088-3106. doi: 10.1021/acs.jmedchem.8b01971. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30843696

8

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT_2C) receptor agonist without 5-HT_2B agonism.

Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Zhang G, et al. Among authors: cheng j. Eur J Med Chem. 2019 Nov 15;182:111626. doi: 10.1016/j.ejmech.2019.111626. Epub 2019 Aug 14. Eur J Med Chem. 2019. PMID: 31445232 Free PMC article.

9

Enhancing the Signaling of GPCRs via Orthosteric Ions.

Chan HCS, Xu Y, Tan L, Vogel H, Cheng J, Wu D, Yuan S. Chan HCS, et al. Among authors: cheng j. ACS Cent Sci. 2020 Feb 26;6(2):274-282. doi: 10.1021/acscentsci.9b01247. Epub 2020 Jan 23. ACS Cent Sci. 2020. PMID: 32123746 Free PMC article.

10

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

Tan L, Zhou Q, Yan W, Sun J, Kozikowski AP, Zhao S, Huang XP, Cheng J. Tan L, et al. Among authors: cheng j. J Med Chem. 2020 May 14;63(9):4579-4602. doi: 10.1021/acs.jmedchem.9b01835. Epub 2020 Apr 23. J Med Chem. 2020. PMID: 32282200

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