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PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer.
Guigon CJ, Zhao L, Willingham MC, Cheng SY. Guigon CJ, et al. Oncogene. 2009 Jan 29;28(4):509-17. doi: 10.1038/onc.2008.407. Epub 2008 Nov 10. Oncogene. 2009. PMID: 18997818 Free PMC article.
The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer.
Ying H, Willingham MC, Cheng SY. Ying H, et al. Oncogene. 2008 Jan 31;27(6):823-30. doi: 10.1038/sj.onc.1210680. Epub 2007 Jul 23. Oncogene. 2008. PMID: 17653082
Further, in vivo and in vitro analyses of multiple signaling pathways indicated that SRC-3 deficiency could lead to (1) inhibition of cell cycle progression at the G(1)/S transition via controlling the expression of cell cycle regulators, such as E2F1; (2) induction of apo …
Further, in vivo and in vitro analyses of multiple signaling pathways indicated that SRC-3 deficiency could lead to (1) inhibition of cell c …
Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.
Suzuki H, Zhang XY, Forrest D, Willingham MC, Cheng SY. Suzuki H, et al. Mol Endocrinol. 2003 May;17(5):895-907. doi: 10.1210/me.2002-0326. Epub 2003 Feb 6. Mol Endocrinol. 2003. PMID: 12576488
The tumor suppressor p53 is a negative regulator of estrogen receptor signaling pathways.
Yu CL, Driggers P, Barrera-Hernandez G, Nunez SB, Segars JH, Cheng S. Yu CL, et al. Biochem Biophys Res Commun. 1997 Oct 20;239(2):617-20. doi: 10.1006/bbrc.1997.7522. Biochem Biophys Res Commun. 1997. PMID: 9344880
A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.
Kaneshige M, Suzuki H, Kaneshige K, Cheng J, Wimbrow H, Barlow C, Willingham MC, Cheng S. Kaneshige M, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15095-100. doi: 10.1073/pnas.261565798. Epub 2001 Dec 4. Proc Natl Acad Sci U S A. 2001. PMID: 11734632 Free PMC article.
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