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Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease.
Dodge JC, Clarke J, Song A, Bu J, Yang W, Taksir TV, Griffiths D, Zhao MA, Schuchman EH, Cheng SH, O'Riordan CR, Shihabuddin LS, Passini MA, Stewart GR. Dodge JC, et al. Among authors: cheng sh. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17822-7. doi: 10.1073/pnas.0509062102. Epub 2005 Nov 21. Proc Natl Acad Sci U S A. 2005. PMID: 16301517 Free PMC article.
Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.
Passini MA, Bu J, Fidler JA, Ziegler RJ, Foley JW, Dodge JC, Yang WW, Clarke J, Taksir TV, Griffiths DA, Zhao MA, O'Riordan CR, Schuchman EH, Shihabuddin LS, Cheng SH. Passini MA, et al. Among authors: cheng sh. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9505-10. doi: 10.1073/pnas.0703509104. Epub 2007 May 21. Proc Natl Acad Sci U S A. 2007. PMID: 17517638 Free PMC article.
Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease.
Cabrera-Salazar MA, Roskelley EM, Bu J, Hodges BL, Yew N, Dodge JC, Shihabuddin LS, Sohar I, Sleat DE, Scheule RK, Davidson BL, Cheng SH, Lobel P, Passini MA. Cabrera-Salazar MA, et al. Among authors: cheng sh. Mol Ther. 2007 Oct;15(10):1782-8. doi: 10.1038/sj.mt.6300249. Epub 2007 Jul 17. Mol Ther. 2007. PMID: 17637720 Free article.
Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.
Dodge JC, Haidet AM, Yang W, Passini MA, Hester M, Clarke J, Roskelley EM, Treleaven CM, Rizo L, Martin H, Kim SH, Kaspar R, Taksir TV, Griffiths DA, Cheng SH, Shihabuddin LS, Kaspar BK. Dodge JC, et al. Among authors: cheng sh. Mol Ther. 2008 Jun;16(6):1056-64. doi: 10.1038/mt.2008.60. Epub 2008 Apr 1. Mol Ther. 2008. PMID: 18388910 Free PMC article.
984 results