Chern JW - Search Results

1

Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice.

Prijovich ZM, Chen BM, Leu YL, Chern JW, Roffler SR. Prijovich ZM, et al. Among authors: chern jw. Br J Cancer. 2002 May 20;86(10):1634-8. doi: 10.1038/sj.bjc.6600317. Br J Cancer. 2002. PMID: 12085215 Free PMC article.

2

Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats.

Peng IH, Sheu JR, Chern JW, Lee YM, Yen MH. Peng IH, et al. Among authors: chern jw. J Biomed Sci. 1996 Apr;3(2):108-116. doi: 10.1007/BF02255538. J Biomed Sci. 1996. PMID: 11725091

3

NS5B RNA dependent RNA polymerase inhibitors: the promising approach to treat hepatitis C virus infections.

Deore RR, Chern JW. Deore RR, et al. Among authors: chern jw. Curr Med Chem. 2010;17(32):3806-26. doi: 10.2174/092986710793205471. Curr Med Chem. 2010. PMID: 20858218 Review.

4

2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with inbuilt β-N-hydroxy-γ-keto-acid pharmacophore as HCV NS5B polymerase inhibitors.

Deore RR, Chen GS, Chen CS, Chang PT, Chuang MH, Chern TR, Wang HC, Chern JW. Deore RR, et al. Among authors: chern tr, chern jw. Curr Med Chem. 2012;19(4):613-24. doi: 10.2174/092986712798918833. Curr Med Chem. 2012. PMID: 22204334 Review.

5

Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.

Peng C, Li YH, Yu CW, Cheng ZH, Liu JR, Hsu JL, Hsin LW, Huang CT, Juan HF, Chern JW, Cheng YS. Peng C, et al. Among authors: chern jw. Bioorg Chem. 2021 May;110:104813. doi: 10.1016/j.bioorg.2021.104813. Epub 2021 Mar 10. Bioorg Chem. 2021. PMID: 33774493 Free article.

6

Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.

Hsieh CM, Chen CY, Chern JW, Chan NL. Hsieh CM, et al. Among authors: chern jw. J Med Chem. 2020 Aug 13;63(15):8485-8494. doi: 10.1021/acs.jmedchem.0c00853. Epub 2020 Jul 27. J Med Chem. 2020. PMID: 32663396

7

4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.

Jagtap AD, Kondekar NB, Hung PY, Hsieh CE, Yang CR, Chen GS, Chern JW. Jagtap AD, et al. Among authors: chern jw. Bioorg Chem. 2020 Jan;95:103135. doi: 10.1016/j.bioorg.2019.103135. Epub 2019 Jul 22. Bioorg Chem. 2020. PMID: 31923631

8

High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma.

Liu JR, Yu CW, Hung PY, Hsin LW, Chern JW. Liu JR, et al. Among authors: chern jw. Biochem Pharmacol. 2019 May;163:458-471. doi: 10.1016/j.bcp.2019.03.023. Epub 2019 Mar 15. Biochem Pharmacol. 2019. PMID: 30885763

9

Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.

Wu KD, Chen GS, Liu JR, Hsieh CE, Chern JW. Wu KD, et al. Among authors: chern jw. ACS Med Chem Lett. 2018 Dec 6;10(1):22-26. doi: 10.1021/acsmedchemlett.8b00270. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655941 Free PMC article.

10

Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.

Yu CW, Hung PY, Yang HT, Ho YH, Lai HY, Cheng YS, Chern JW. Yu CW, et al. Among authors: chern jw. J Med Chem. 2019 Jan 24;62(2):857-874. doi: 10.1021/acs.jmedchem.8b01590. Epub 2018 Dec 20. J Med Chem. 2019. PMID: 30525585

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