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A tale of two Paks.
Arias-Romero LE, Chernoff J. Arias-Romero LE, et al. Among authors: chernoff j. Biol Cell. 2008 Feb;100(2):97-108. doi: 10.1042/BC20070109. Biol Cell. 2008. PMID: 18199048 Review.
Cloning and characterization of a human protein kinase with homology to Ste20.
Creasy CL, Chernoff J. Creasy CL, et al. Among authors: chernoff j. J Biol Chem. 1995 Sep 15;270(37):21695-700. doi: 10.1074/jbc.270.37.21695. J Biol Chem. 1995. PMID: 7665586
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.
Patriotis C, Makris A, Chernoff J, Tsichlis PN. Patriotis C, et al. Among authors: chernoff j. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9755-9. doi: 10.1073/pnas.91.21.9755. Proc Natl Acad Sci U S A. 1994. PMID: 7937886 Free PMC article.
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.
Creasy CL, Chernoff J. Creasy CL, et al. Among authors: chernoff j. Gene. 1995 Dec 29;167(1-2):303-6. doi: 10.1016/0378-1119(95)00653-2. Gene. 1995. PMID: 8566796
The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain.
Creasy CL, Ambrose DM, Chernoff J. Creasy CL, et al. Among authors: chernoff j. J Biol Chem. 1996 Aug 30;271(35):21049-53. doi: 10.1074/jbc.271.35.21049. J Biol Chem. 1996. PMID: 8702870
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.
Tang Y, Chen Z, Ambrose D, Liu J, Gibbs JB, Chernoff J, Field J. Tang Y, et al. Among authors: chernoff j. Mol Cell Biol. 1997 Aug;17(8):4454-64. doi: 10.1128/mcb.17.8.4454. Mol Cell Biol. 1997. PMID: 9234703 Free PMC article.
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.
Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. Sells MA, et al. Among authors: chernoff j. Curr Biol. 1997 Mar 1;7(3):202-10. doi: 10.1016/s0960-9822(97)70091-5. Curr Biol. 1997. PMID: 9395435
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand.
Liu F, Sells MA, Chernoff J. Liu F, et al. Among authors: chernoff j. Mol Cell Biol. 1998 Jan;18(1):250-9. doi: 10.1128/mcb.18.1.250. Mol Cell Biol. 1998. PMID: 9418872 Free PMC article.
Expression of wild-type PTP1B (WT-PTP1B), but not a catalytically competent, proline-to-alanine point mutant that cannot bind p130Cas (PA-PTP1B), causes substantial tyrosine dephosphorylation of p130Cas (F. Liu, D. E. Hill, and J. Chernoff, J. Biol. Chem. 271 …
Expression of wild-type PTP1B (WT-PTP1B), but not a catalytically competent, proline-to-alanine point mutant that cannot bind p130Cas (PA-PT …
Protein tyrosine phosphatase 1B negatively regulates integrin signaling.
Liu F, Sells MA, Chernoff J. Liu F, et al. Among authors: chernoff j. Curr Biol. 1998 Jan 29;8(3):173-6. doi: 10.1016/s0960-9822(98)70066-1. Curr Biol. 1998. PMID: 9443918
Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.
Sells MA, Barratt JT, Caviston J, Ottilie S, Leberer E, Chernoff J. Sells MA, et al. Among authors: chernoff j. J Biol Chem. 1998 Jul 17;273(29):18490-8. doi: 10.1074/jbc.273.29.18490. J Biol Chem. 1998. PMID: 9660818
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