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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat JL, Kanellopoulos J, Martin F, Rébé C, Apetoh L, Ghiringhelli F. Bruchard M, et al. Among authors: chevriaux a. Nat Med. 2013 Jan;19(1):57-64. doi: 10.1038/nm.2999. Epub 2012 Dec 2. Nat Med. 2013. PMID: 23202296
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.
Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, Martin F, Apetoh L, Rébé C, Ghiringhelli F. Vincent J, et al. Among authors: chevriaux a. Cancer Res. 2010 Apr 15;70(8):3052-61. doi: 10.1158/0008-5472.CAN-09-3690. Epub 2010 Apr 13. Cancer Res. 2010. PMID: 20388795
In vivo, the treatment of tumor-bearing mice with 5FU led to a major decrease in the number of MDSC in the spleens and tumor beds of animals whereas no significant effect on T cells, natural killer cells, dendritic cells, or B cells was noted. Interestingly, 5FU showed …
In vivo, the treatment of tumor-bearing mice with 5FU led to a major decrease in the number of MDSC in the spleens and tumor beds of …
Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D. Sberna AL, et al. Among authors: chevriaux a. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2232-9. doi: 10.1161/ATVBAHA.110.222497. Epub 2011 Jul 21. Arterioscler Thromb Vasc Biol. 2011. PMID: 21778422 Free PMC article.
These mice also showed a significant reduction in the production of very-low-density lipoproteins associated with a decrease in hepatic triglyceride content and the repression of several genes involved in lipogenesis. ...CONCLUSIONS: CAR is a potential target …
These mice also showed a significant reduction in the production of very-low-density lipoproteins associated with a decrease i …
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.
Chalmin F, Mignot G, Bruchard M, Chevriaux A, Végran F, Hichami A, Ladoire S, Derangère V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rébé C, Ghiringhelli F. Chalmin F, et al. Among authors: chevriaux a. Immunity. 2012 Mar 23;36(3):362-73. doi: 10.1016/j.immuni.2011.12.019. Epub 2012 Mar 8. Immunity. 2012. PMID: 22406269
Finally, adoptive transfer of Th17 cells induced by TGF-betaand IL-6 promoted tumor growth in a CD39-dependent manner. Thus, ectonucleotidase expression supports the immunosuppressive fate of Th17 cells in cancer....
Finally, adoptive transfer of Th17 cells induced by TGF-betaand IL-6 promoted tumor growth in a CD39-dependent manner. Thus, ectonucl …
Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes.
Rébé C, Filomenko R, Raveneau M, Chevriaux A, Ishibashi M, Lagrost L, Junien JL, Gambert P, Masson D. Rébé C, et al. Among authors: chevriaux a. PLoS One. 2012;7(11):e48738. doi: 10.1371/journal.pone.0048738. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185273 Free PMC article.
The three CD were up-regulated by LXR agonist treatment in vitro in a time- and dose- dependent manner and this induction was LXR specific as assessed by a SiRNA or LXR antagonist strategy. ...
The three CD were up-regulated by LXR agonist treatment in vitro in a time- and dose- dependent manner and this induction was LXR spe …
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Ishibashi M, Filomenko R, Rébé C, Chevriaux A, Varin A, Derangère V, Bessède G, Gambert P, Lagrost L, Masson D. Ishibashi M, et al. Among authors: chevriaux a. Biochem Pharmacol. 2013 Jul 1;86(1):122-9. doi: 10.1016/j.bcp.2012.12.024. Epub 2013 Jan 9. Biochem Pharmacol. 2013. PMID: 23313547
In contrast to earlier mouse studies, LXRalphalevels appear as a limiting factor for macrophage cholesterol efflux in humans....
In contrast to earlier mouse studies, LXRalphalevels appear as a limiting factor for macrophage cholesterol efflux in humans....
SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.
Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, Chevriaux A, Rébé C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L. Berger H, et al. Among authors: chevriaux a. Cancer Res. 2013 Jun 15;73(12):3578-90. doi: 10.1158/0008-5472.CAN-12-4018. Epub 2013 Apr 25. Cancer Res. 2013. PMID: 23619236
Here, we identify the adapter-encoding gene SOCS3 as a critical transcriptional target of PPARgamma. SOCS3 promoter binding and gene transactivation by PPARgammawas associated with a repression in differentiation of proinflammatory T-helper (TH)17 cells. ...Furtherm …
Here, we identify the adapter-encoding gene SOCS3 as a critical transcriptional target of PPARgamma. SOCS3 promoter binding and gene …
Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells.
Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, Causse SZ, Limagne E, Végran F, Ladoire S, Simon B, Boireau W, Hichami A, Apetoh L, Mignot G, Ghiringhelli F, Rébé C. Derangère V, et al. Among authors: chevriaux a. Cell Death Differ. 2014 Dec;21(12):1914-24. doi: 10.1038/cdd.2014.117. Epub 2014 Aug 15. Cell Death Differ. 2014. PMID: 25124554 Free PMC article.
Surprisingly, LXRbetais mainly located in the cytoplasm and has a non-genomic role by interacting with pannexin 1 leading to ATP secretion. Finally, LXR ligands have an antitumoral effect in a mouse colon cancer model, dependent on the presence of LXRbeta, pannexin …
Surprisingly, LXRbetais mainly located in the cytoplasm and has a non-genomic role by interacting with pannexin 1 leading to ATP secr …
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F. Bruchard M, et al. Among authors: chevriaux a. Nat Immunol. 2015 Aug;16(8):859-70. doi: 10.1038/ni.3202. Epub 2015 Jun 22. Nat Immunol. 2015. PMID: 26098997
Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization.
Courtaut F, Derangère V, Chevriaux A, Ladoire S, Cotte AK, Arnould L, Boidot R, Rialland M, Ghiringhelli F, Rébé C. Courtaut F, et al. Among authors: chevriaux a. Oncotarget. 2015 Sep 29;6(29):26651-62. doi: 10.18632/oncotarget.5791. Oncotarget. 2015. PMID: 26450852 Free PMC article.
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