Chhabra S - Search Results

1

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins.

Swarbrick JD, Shaw DJ, Chhabra S, Ghai R, Valkov E, Norwood SJ, Seaman MN, Collins BM. Swarbrick JD, et al. Among authors: chhabra s. PLoS One. 2011;6(5):e20420. doi: 10.1371/journal.pone.0020420. Epub 2011 May 24. PLoS One. 2011. PMID: 21629666 Free PMC article.

2

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor.

Chhabra S, Dolezal O, Collins BM, Newman J, Simpson JS, Macreadie IG, Fernley R, Peat TS, Swarbrick JD. Chhabra S, et al. PLoS One. 2012;7(1):e29444. doi: 10.1371/journal.pone.0029444. Epub 2012 Jan 19. PLoS One. 2012. PMID: 22276115 Free PMC article.

3

An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy.

Swarbrick JD, Ung P, Chhabra S, Graham B. Swarbrick JD, et al. Among authors: chhabra s. Angew Chem Int Ed Engl. 2011 May 2;50(19):4403-6. doi: 10.1002/anie.201007221. Epub 2011 Apr 7. Angew Chem Int Ed Engl. 2011. PMID: 21480444 No abstract available.

4

Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy.

Swarbrick JD, Ung P, Su XC, Maleckis A, Chhabra S, Huber T, Otting G, Graham B. Swarbrick JD, et al. Among authors: chhabra s. Chem Commun (Camb). 2011 Jul 14;47(26):7368-70. doi: 10.1039/c1cc11893e. Epub 2011 May 27. Chem Commun (Camb). 2011. PMID: 21617818

5

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.

Chhabra S, Barlow N, Dolezal O, Hattarki MK, Newman J, Peat TS, Graham B, Swarbrick JD. Chhabra S, et al. PLoS One. 2013;8(4):e59535. doi: 10.1371/journal.pone.0059535. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565155 Free PMC article.

6

Installation of a Rigid EDTA-Like Motif into a Protein α-Helix for Paramagnetic NMR Spectroscopy with Cobalt(II) Ions.

Swarbrick JD, Ung P, Dennis ML, Lee MD, Chhabra S, Graham B. Swarbrick JD, et al. Among authors: chhabra s. Chemistry. 2016 Jan 22;22(4):1228-32. doi: 10.1002/chem.201503139. Epub 2015 Dec 17. Chemistry. 2016. PMID: 26634335

7

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Chhabra S, Newman J, Peat TS, Fernley RT, Caine J, Simpson JS, Swarbrick JD. Chhabra S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):575-8. doi: 10.1107/S1744309110010857. Epub 2010 Apr 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20445263 Free PMC article.

8

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: chhabra s. J Med Chem. 2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25357262

9

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra.

Graham B, Loh CT, Swarbrick JD, Ung P, Shin J, Yagi H, Jia X, Chhabra S, Barlow N, Pintacuda G, Huber T, Otting G. Graham B, et al. Among authors: chhabra s. Bioconjug Chem. 2011 Oct 19;22(10):2118-25. doi: 10.1021/bc200353c. Epub 2011 Sep 20. Bioconjug Chem. 2011. PMID: 21877751

10

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

Dennis ML, Lee MD, Harjani JR, Ahmed M, DeBono AJ, Pitcher NP, Wang ZC, Chhabra S, Barlow N, Rahmani R, Cleary B, Dolezal O, Hattarki M, Aurelio L, Shonberg J, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: chhabra s. Chemistry. 2018 Feb 6;24(8):1922-1930. doi: 10.1002/chem.201704730. Epub 2018 Jan 9. Chemistry. 2018. PMID: 29171692

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