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Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.
Formentini L, Moroni F, Chiarugi A. Formentini L, et al. Among authors: chiarugi a. Biochem Pharmacol. 2009 May 15;77(10):1612-20. doi: 10.1016/j.bcp.2009.02.017. Epub 2009 Mar 5. Biochem Pharmacol. 2009. PMID: 19426698
Here, we describe a new method of fluorimetric NMN detection upon derivatization of its alkylpyridinium group with acetophenone. ...Data provide new information on the biochemistry and pharmacology of NAD biosynthesis, allowing a better understanding of pyridine nuc …
Here, we describe a new method of fluorimetric NMN detection upon derivatization of its alkylpyridinium group with acetophenone. ...D …
Identification and measurement of oxindole (2-indolinone) in the mammalian brain and other rat organs.
Carpenedo R, Carlà V, Moneti G, Chiarugi A, Moroni F. Carpenedo R, et al. Among authors: chiarugi a. Anal Biochem. 1997 Jan 1;244(1):74-9. doi: 10.1006/abio.1996.9854. Anal Biochem. 1997. PMID: 9025911
Oxindole, a putative tryptophan metabolite able to cause profound sedation when administered in relatively low doses to mammals, has been identified and measured in the brains of mice, rats, and guinea pigs using HPLC and GC/MS with a quadrupole ion trap and a
Oxindole, a putative tryptophan metabolite able to cause profound sedation when administered in relatively low doses to mammals, has …
Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid.
Chiarugi A, Meli E, Moroni F. Chiarugi A, et al. J Neurochem. 2001 Jun;77(5):1310-8. doi: 10.1046/j.1471-4159.2001.00335.x. J Neurochem. 2001. PMID: 11389182
In primary cultures of mixed cortical cells, the minimal concentration of these compounds leading to a significant degree of neurotoxicity decreased from 100 to 1 microM, when the exposure time was prolonged from 24 to 72 h. ...Because minor changes in the physiological co …
In primary cultures of mixed cortical cells, the minimal concentration of these compounds leading to a significant degree of neurotox …
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Chiarugi A, Calvani M, Meli E, Traggiai E, Moroni F. Chiarugi A, et al. J Neuroimmunol. 2001 Nov 1;120(1-2):190-8. doi: 10.1016/s0165-5728(01)00418-0. J Neuroimmunol. 2001. PMID: 11694334
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.
Chiarugi A. Chiarugi A. Br J Pharmacol. 2002 Nov;137(6):761-70. doi: 10.1038/sj.bjp.0704934. Br J Pharmacol. 2002. PMID: 12411406 Free PMC article.
By contrast, a robust formation of poly(ADP-ribose) occurred in B- and T-cell areas in lymph nodes of myelin-immunized rats and was suppressed by the treatment with 6(5H)-phenanthridinone and benzamide. ...
By contrast, a robust formation of poly(ADP-ribose) occurred in B- and T-cell areas in lymph nodes of myelin-immunized rats and was s …
Tryptophan availability selectively limits NO-synthase induction in macrophages.
Chiarugi A, Rovida E, Dello Sbarba P, Moroni F. Chiarugi A, et al. J Leukoc Biol. 2003 Jan;73(1):172-7. doi: 10.1189/jlb.0502220. J Leukoc Biol. 2003. PMID: 12525575
Our results suggest that a reduced local TRP availability may modify macrophage function and possibly the outcome of immune responses....
Our results suggest that a reduced local TRP availability may modify macrophage function and possibly the outcome of immune responses …
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
Chiarugi A, Meli E, Calvani M, Picca R, Baronti R, Camaioni E, Costantino G, Marinozzi M, Pellegrini-Giampietro DE, Pellicciari R, Moroni F. Chiarugi A, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):943-9. doi: 10.1124/jpet.103.048934. Epub 2003 Feb 20. J Pharmacol Exp Ther. 2003. PMID: 12606624
Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and ATP depletion and has been proposed to play a causative role in …
Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD …
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage.
Meli E, Pangallo M, Baronti R, Chiarugi A, Cozzi A, Pellegrini-Giampietro DE, Moroni F. Meli E, et al. Among authors: chiarugi a. Toxicol Lett. 2003 Apr 4;139(2-3):153-62. doi: 10.1016/s0378-4274(02)00429-0. Toxicol Lett. 2003. PMID: 12628750
Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins. ...Known family members are PARP-1, PARP-2, PARP-3, vPARP, tankyrase 1 and t …
Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transf …
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes.
Rapizzi E, Fossati S, Moroni F, Chiarugi A. Rapizzi E, et al. Among authors: chiarugi a. Mol Pharmacol. 2004 Oct;66(4):890-8. doi: 10.1124/mol.104.000968. Epub 2004 Jun 30. Mol Pharmacol. 2004. PMID: 15229295
Consistent with a PAR-dependent transcriptional activation, increases of iNOS and COX-2 transcripts were not caused by activation of transcription factors such as nuclear factor-kappaB, activator protein-1, signal transducer and activator of transcription-1 or interferon r …
Consistent with a PAR-dependent transcriptional activation, increases of iNOS and COX-2 transcripts were not caused by activation of …
The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension.
Porcu M, Chiarugi A. Porcu M, et al. Among authors: chiarugi a. Trends Pharmacol Sci. 2005 Feb;26(2):94-103. doi: 10.1016/j.tips.2004.12.009. Trends Pharmacol Sci. 2005. PMID: 15681027 Review.
Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging. ...
Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pat …
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