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Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling.
Yamamoto S, Nakase H, Matsuura M, Honzawa Y, Matsumura K, Uza N, Yamaguchi Y, Mizoguchi E, Chiba T. Yamamoto S, et al. Among authors: chiba t. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G241-9. doi: 10.1152/ajpgi.00480.2012. Epub 2013 Jun 6. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23744737 Free PMC article.
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T, Seno H, Nishi E, Chiba T. Kanda K, et al. Among authors: chiba t. EMBO Mol Med. 2012 May;4(5):396-411. doi: 10.1002/emmm.201200216. Epub 2012 Feb 20. EMBO Mol Med. 2012. PMID: 22351606 Free PMC article.
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