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Open PHACTS: semantic interoperability for drug discovery.
Williams AJ, Harland L, Groth P, Pettifer S, Chichester C, Willighagen EL, Evelo CT, Blomberg N, Ecker G, Goble C, Mons B. Williams AJ, et al. Among authors: chichester c. Drug Discov Today. 2012 Nov;17(21-22):1188-98. doi: 10.1016/j.drudis.2012.05.016. Epub 2012 Jun 7. Drug Discov Today. 2012. PMID: 22683805 Free article. Review.
Scientific competency questions as the basis for semantically enriched open pharmacological space development.
Azzaoui K, Jacoby E, Senger S, Rodríguez EC, Loza M, Zdrazil B, Pinto M, Williams AJ, de la Torre V, Mestres J, Pastor M, Taboureau O, Rarey M, Chichester C, Pettifer S, Blomberg N, Harland L, Williams-Jones B, Ecker GF. Azzaoui K, et al. Among authors: chichester c. Drug Discov Today. 2013 Sep;18(17-18):843-52. doi: 10.1016/j.drudis.2013.05.008. Epub 2013 May 20. Drug Discov Today. 2013. PMID: 23702085 Free article. Review.
The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.
Ratnam J, Zdrazil B, Digles D, Cuadrado-Rodriguez E, Neefs JM, Tipney H, Siebes R, Waagmeester A, Bradley G, Chau CH, Richter L, Brea J, Evelo CT, Jacoby E, Senger S, Loza MI, Ecker GF, Chichester C. Ratnam J, et al. Among authors: chichester c. PLoS One. 2014 Dec 18;9(12):e115460. doi: 10.1371/journal.pone.0115460. eCollection 2014. PLoS One. 2014. PMID: 25522365 Free PMC article.
Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.
Digles D, Zdrazil B, Neefs JM, Van Vlijmen H, Herhaus C, Caracoti A, Brea J, Roibás B, Loza MI, Queralt-Rosinach N, Furlong LI, Gaulton A, Bartek L, Senger S, Chichester C, Engkvist O, Evelo CT, Franklin NI, Marren D, Ecker GF, Jacoby E. Digles D, et al. Among authors: chichester c. Medchemcomm. 2016 Jun 1;7(6):1237-1244. doi: 10.1039/c6md00065g. Epub 2016 May 11. Medchemcomm. 2016. PMID: 27774140 Free PMC article.
Annotating Human P-Glycoprotein Bioassay Data.
Zdrazil B, Pinto M, Vasanthanathan P, Williams AJ, Balderud LZ, Engkvist O, Chichester C, Hersey A, Overington JP, Ecker GF. Zdrazil B, et al. Among authors: chichester c. Mol Inform. 2012 Aug;31(8):599-609. doi: 10.1002/minf.201200059. Epub 2012 Aug 7. Mol Inform. 2012. PMID: 23293680 Free PMC article.
Calling on a million minds for community annotation in WikiProteins.
Mons B, Ashburner M, Chichester C, van Mulligen E, Weeber M, den Dunnen J, van Ommen GJ, Musen M, Cockerill M, Hermjakob H, Mons A, Packer A, Pacheco R, Lewis S, Berkeley A, Melton W, Barris N, Wales J, Meijssen G, Moeller E, Roes PJ, Borner K, Bairoch A. Mons B, et al. Among authors: chichester c. Genome Biol. 2008;9(5):R89. doi: 10.1186/gb-2008-9-5-r89. Epub 2008 May 28. Genome Biol. 2008. PMID: 18507872 Free PMC article.
The value of data.
Mons B, van Haagen H, Chichester C, Hoen PB, den Dunnen JT, van Ommen G, van Mulligen E, Singh B, Hooft R, Roos M, Hammond J, Kiesel B, Giardine B, Velterop J, Groth P, Schultes E. Mons B, et al. Among authors: chichester c. Nat Genet. 2011 Mar 29;43(4):281-3. doi: 10.1038/ng0411-281. Nat Genet. 2011. PMID: 21445068
146 results