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Comparative morphological analysis of the geometry of ruptured and unruptured aneurysms.
Chien A, Sayre J, Viñuela F. Chien A, et al. Neurosurgery. 2011 Aug;69(2):349-56. doi: 10.1227/NEU.0b013e31821661c3. Neurosurgery. 2011. PMID: 21415785

RESULTS: More than 65% of ruptured aneurysms had a ratio of aneurysm volume to bounding sphere volume (AVSV) of > 0.5. More than 70% of ruptured aneurysms had a ratio of aneurysm surface to bounding sphere surface (AASA) of < 1. ...CONCLUSION: By comparing ane

RESULTS: More than 65% of ruptured aneurysms had a ratio of aneurysm volume to bounding sphere volume (AVSV) of > 0.5. More than 7 …
Patient-specific flow analysis of brain aneurysms at a single location: comparison of hemodynamic characteristics in small aneurysms.
Chien A, Tateshima S, Castro M, Sayre J, Cebral J, Viñuela F. Chien A, et al. Med Biol Eng Comput. 2008 Nov;46(11):1113-20. doi: 10.1007/s11517-008-0400-5. Epub 2008 Oct 18. Med Biol Eng Comput. 2008. PMID: 18931868
Flow velocity and wall shear stress (WSS) were also quantitatively compared, both in absolute value and relative value using the parent artery as a baseline. ...Hemodynamic analyses at a single location with similar size enabled us to directly compare the hemodynami …
Flow velocity and wall shear stress (WSS) were also quantitatively compared, both in absolute value and relative value using the parent arte …
Level set based surface capturing in 3D medical images.
Dong B, Chien A, Mao Y, Ye J, Osher S. Dong B, et al. Med Image Comput Comput Assist Interv. 2008;11(Pt 1):162-9. doi: 10.1007/978-3-540-85988-8_20. Med Image Comput Comput Assist Interv. 2008. PMID: 18979744
The current method used to determine aneurysm size is to manually measure the width of the neck and height of the dome on a computer screen. ...This includes applications to clinical image data demonstrating the procedure of accurately capturing a middle cerebral ar …
The current method used to determine aneurysm size is to manually measure the width of the neck and height of the dome on a computer …
Patient-specific hemodynamic analysis of small internal carotid artery-ophthalmic artery aneurysms.
Chien A, Tateshima S, Sayre J, Castro M, Cebral J, Viñuela F. Chien A, et al. Surg Neurol. 2009 Nov;72(5):444-50; discussion 450. doi: 10.1016/j.surneu.2008.12.013. Epub 2009 Mar 29. Surg Neurol. 2009. PMID: 19329152
Previous studies have indicated a variety of hemodynamic properties that may influence aneurysm rupture. This study uses hemodynamic principles to evaluate these in the context of ruptured and unruptured small aneurysms in a single location. ...In particular, WSS ma …
Previous studies have indicated a variety of hemodynamic properties that may influence aneurysm rupture. This study uses hemodynamic …
Quantitative hemodynamic analysis of brain aneurysms at different locations.
Chien A, Castro MA, Tateshima S, Sayre J, Cebral J, Viñuela F. Chien A, et al. AJNR Am J Neuroradiol. 2009 Sep;30(8):1507-12. doi: 10.3174/ajnr.A1600. Epub 2009 Apr 30. AJNR Am J Neuroradiol. 2009. PMID: 19406766 Free PMC article.
To validate our method, a comparison with a previously reported technique was also performed. RESULTS: WSS and flow rate in the aneurysms at the peak of the cardiac cycle were found to differ in magnitude between different locations. ...Further study of aneurysm loc …
To validate our method, a comparison with a previously reported technique was also performed. RESULTS: WSS and flow rate in th …
The effect of aneurysm geometry on the intra-aneurysmal flow condition.
Tateshima S, Chien A, Sayre J, Cebral J, Viñuela F. Tateshima S, et al. Neuroradiology. 2010 Dec;52(12):1135-41. doi: 10.1007/s00234-010-0687-4. Epub 2010 Apr 7. Neuroradiology. 2010. PMID: 20373097 Free PMC article.
The largest dome diameter showed a negative correlation with intra-aneurysmal flow velocity (r= -0.731) and WSS (r= -0.496). ...A clear negative correlation was seen between the intra-aneurysmal flow velocity and the dome-neck ratio (r= -0.708). A weak negati …
The largest dome diameter showed a negative correlation with intra-aneurysmal flow velocity (r= -0.731) and WSS (r= -0.496). ...A
3D quantitative evaluation of atherosclerotic plaque based on rotational angiography.
Chien A, Sayre J, Dong B, Ye J, Viñuela F. Chien A, et al. AJNR Am J Neuroradiol. 2011 Aug;32(7):1249-54. doi: 10.3174/ajnr.A2483. Epub 2011 May 19. AJNR Am J Neuroradiol. 2011. PMID: 21596803
BACKGROUND AND PURPOSE: Atherosclerosis is a systemic disease that has been shown to cause various cardiovascular diseases and stroke. ...Further validation in a larger clinical series is required to assess the ultimate value of the present technique....
BACKGROUND AND PURPOSE: Atherosclerosis is a systemic disease that has been shown to cause various cardiovascular diseases and stroke …
IS FlowMap, a novel tool to examine blood flow changes induced by flow diverter stent treatment: initial experiences with pipeline cases.
Chien A, Viñuela F. Chien A, et al. J Neurointerv Surg. 2013 Nov;5 Suppl 3:iii43-7. doi: 10.1136/neurintsurg-2012-010613. Epub 2013 Feb 6. J Neurointerv Surg. 2013. PMID: 23390037
BACKGROUND: Intracranial aneurysm flow diverting stents are a new endovascular treatment option for wide neck and large/giant aneurysms. ...CONCLUSIONS: We present a novel approach to map blood flow motion within aneurysms and have shown the feasibility of the techn …
BACKGROUND: Intracranial aneurysm flow diverting stents are a new endovascular treatment option for wide neck and large/giant aneurys …
Distinct trends of pulsatility found at the necks of ruptured and unruptured aneurysms.
Patti J, Viñuela F, Chien A. Patti J, et al. J Neurointerv Surg. 2014 Mar;6(2):103-7. doi: 10.1136/neurintsurg-2013-010660. Epub 2013 Feb 15. J Neurointerv Surg. 2014. PMID: 23416784
OBJECTIVE: To investigate differences in pulsatility within a group of ruptured and unruptured aneurysms by implementing patient-specific pulsatile flow simulation. ...CONCLUSIONS: A trend towards a lower PI, similar to that in the parent artery, was found in …
OBJECTIVE: To investigate differences in pulsatility within a group of ruptured and unruptured aneurysms by implementing patient-spec …
Quantitative comparison of the dynamic flow waveform changes in 12 ruptured and 29 unruptured ICA-ophthalmic artery aneurysms.
Chien A, Sayre J, Viñuela F. Chien A, et al. Neuroradiology. 2013 Feb;55(3):313-20. doi: 10.1007/s00234-012-1108-7. Epub 2013 Feb 27. Neuroradiology. 2013. PMID: 23443738 Free PMC article.
INTRODUCTION: Studies have reported a correlation between blood flow dynamics in the cardiac cycle and vascular diseases, but research to analyze the dynamic changes of flow in cerebral aneurysms is limited. This quantitative study investigates the temporal changes in flow …
INTRODUCTION: Studies have reported a correlation between blood flow dynamics in the cardiac cycle and vascular diseases, but researc …
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