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Cellular and transgenic models of familial prion diseases.
Harris DA, Chiesa R, Migheli A, Piccardo P, Ghetti B. Harris DA, et al. Among authors: chiesa r. Methods Mol Med. 2001;59:149-61. doi: 10.1385/1-59259-134-5:149. Methods Mol Med. 2001. PMID: 21374503
Primary myopathy and accumulation of PrPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation.
Chiesa R, Pestronk A, Schmidt RE, Tourtellotte WG, Ghetti B, Piccardo P, Harris DA. Chiesa R, et al. Neurobiol Dis. 2001 Apr;8(2):279-88. doi: 10.1006/nbdi.2001.0400. Neurobiol Dis. 2001. PMID: 11300723
A transgenic model of a familial prion disease.
Harris DA, Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, Ghetti B. Harris DA, et al. Among authors: chiesa r. Arch Virol Suppl. 2000;(16):103-12. doi: 10.1007/978-3-7091-6308-5_9. Arch Virol Suppl. 2000. PMID: 11214912 Review.
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.
Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, Ghetti B, Harris DA. Chiesa R, et al. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5574-9. doi: 10.1073/pnas.97.10.5574. Proc Natl Acad Sci U S A. 2000. PMID: 10805813 Free PMC article.
Evidence for a six-transmembrane domain structure of presenilin 1.
Lehmann S, Chiesa R, Harris DA. Lehmann S, et al. Among authors: chiesa r. J Biol Chem. 1997 May 2;272(18):12047-51. doi: 10.1074/jbc.272.18.12047. J Biol Chem. 1997. PMID: 9115271
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation.
Drisaldi B, Stewart RS, Adles C, Stewart LR, Quaglio E, Biasini E, Fioriti L, Chiesa R, Harris DA. Drisaldi B, et al. Among authors: chiesa r. J Biol Chem. 2003 Jun 13;278(24):21732-43. doi: 10.1074/jbc.M213247200. Epub 2003 Mar 26. J Biol Chem. 2003. PMID: 12663673
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.
Massignan T, Stewart RS, Biasini E, Solomon IH, Bonetto V, Chiesa R, Harris DA. Massignan T, et al. Among authors: chiesa r. J Biol Chem. 2010 Mar 5;285(10):7752-65. doi: 10.1074/jbc.M109.064949. Epub 2009 Nov 24. J Biol Chem. 2010. PMID: 19940127 Free PMC article.
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