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Update on pediatric testicular germ cell tumors.
Aldrink JH, Glick RD, Baertschiger RM, Kulaylat AN, Lautz TB, Christison-Lagay E, Grant CN, Tracy E, Dasgupta R, Brown EG, Mattei P, Rothstein DH, Rodeberg DA, Ehrlich PF. Aldrink JH, et al. J Pediatr Surg. 2022 Apr;57(4):690-699. doi: 10.1016/j.jpedsurg.2021.04.001. Epub 2021 Apr 15. J Pediatr Surg. 2022. PMID: 33975708 Review.
METHOD: A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article. RESULTS: In this summary …
METHOD: A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testi …
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C. Litchfield K, et al. Nat Rev Urol. 2016 Jul;13(7):409-19. doi: 10.1038/nrurol.2016.107. Epub 2016 Jun 14. Nat Rev Urol. 2016. PMID: 27296647 Review.
Thirdly, the method of disease formation is unique, with tumours universally stemming from a noninvasive precursor lesion, probably of fetal origin, which lies dormant through childhood into adolescence and then eventually begins malignant growth in early adulthood. ...
Thirdly, the method of disease formation is unique, with tumours universally stemming from a noninvasive precursor lesion, probably of fetal …
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S. Lanciotti L, et al. Int J Environ Res Public Health. 2019 Apr 9;16(7):1268. doi: 10.3390/ijerph16071268. Int J Environ Res Public Health. 2019. PMID: 30970592 Free PMC article. Review.
CAIS management still represents a unique challenge throughout childhood and adolescence, particularly regarding timing of gonadectomy, type of hormonal therapy, and psychological concerns. ...
CAIS management still represents a unique challenge throughout childhood and adolescence, particularly regarding timing of gonadectom …
The fate of germ cells in cryptorchid testis.
Thorup J, Hildorf S, Hildorf AE, Baastrup JM, Mamsen LS, Andersen CY, Olsen TE, Cortes D. Thorup J, et al. Front Endocrinol (Lausanne). 2024 Jan 3;14:1305428. doi: 10.3389/fendo.2023.1305428. eCollection 2023. Front Endocrinol (Lausanne). 2024. PMID: 38234428 Free PMC article. Review.
Infertility in adulthood is closely linked to the germ cell status in childhood. Furthermore, the significance of germ cell status is important as more than 95% of all reported testicular malignancies are germ cell tumors. ...
Infertility in adulthood is closely linked to the germ cell status in childhood. Furthermore, the significance of germ cell status is …
Testicular malignancy in persistent Mullerian duct syndrome: Experience from an apex cancer center with review of literature.
Philips MR, Menon AR, Kumar GR, Malik K, Chandrasekaran S, Ramaswamy T, Narayanaswamy K, Raja A. Philips MR, et al. Urol Oncol. 2023 May;41(5):258.e1-258.e6. doi: 10.1016/j.urolonc.2023.02.008. Epub 2023 Apr 3. Urol Oncol. 2023. PMID: 37019765 Review.
CONCLUSIONS: Testicular cancer in PMDS usually presents in adults with advanced stage disease resulting from neglected or inadequate management of cryptorchidism. Appropriate management of cryptorchidism in childhood is likely to decrease malignant degeneration, if not, en …
CONCLUSIONS: Testicular cancer in PMDS usually presents in adults with advanced stage disease resulting from neglected or inadequate managem …
Testicular microlithiasis: the importance of self-examination.
Price NR, Charlton A, Simango I, Smith GH. Price NR, et al. J Paediatr Child Health. 2014 Oct;50(10):E102-5. doi: 10.1111/j.1440-1754.2011.02021.x. Epub 2011 Mar 10. J Paediatr Child Health. 2014. PMID: 21392148 Review.
We report the third ever case of tumour arising from a testis previously known to have microlithiasis in childhood and review the literature to provide an evidence-based approach to management of testicular microlithiasis. ...RESULTS AND CONCLUSIONS: Although there is a st …
We report the third ever case of tumour arising from a testis previously known to have microlithiasis in childhood and review the lit …