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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: chin en. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
Targeting STING to promote antitumor immunity.
Chin EN, Sulpizio A, Lairson LL. Chin EN, et al. Trends Cell Biol. 2023 Mar;33(3):189-203. doi: 10.1016/j.tcb.2022.06.010. Epub 2022 Aug 2. Trends Cell Biol. 2023. PMID: 35931610 Review.
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Chin EN, et al. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. Science. 2020. PMID: 32820126
A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.
Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL. Lucki NC, et al. Among authors: chin en. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440. doi: 10.1073/pnas.1816626116. Epub 2019 Mar 7. Proc Natl Acad Sci U S A. 2019. PMID: 30846550 Free PMC article.
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.
Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Chang JL, et al. Among authors: chin en. EMBO Rep. 2010 Oct;11(10):765-71. doi: 10.1038/embor.2010.135. Epub 2010 Sep 17. EMBO Rep. 2010. PMID: 20847738 Free PMC article.
33 results