Chiosis G - Search Results

1

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.

Kucine N, Marubayashi S, Bhagwat N, Papalexi E, Koppikar P, Sanchez Martin M, Dong L, Tallman MS, Paietta E, Wang K, He J, Lipson D, Stephens P, Miller V, Rowe JM, Teruya-Feldstein J, Mullighan CG, Ferrando AA, Krivtsov A, Armstrong S, Leung L, Ochiana SO, Chiosis G, Levine RL, Kleppe M. Kucine N, et al. Among authors: chiosis g. Blood. 2015 Nov 26;126(22):2479-83. doi: 10.1182/blood-2015-03-635821. Epub 2015 Oct 6. Blood. 2015. PMID: 26443624 Free PMC article. Clinical Trial.

2

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL. Gorre ME, et al. Among authors: chiosis g. Blood. 2002 Oct 15;100(8):3041-4. doi: 10.1182/blood-2002-05-1361. Blood. 2002. PMID: 12351420 Free article.

3

Development of purine-scaffold small molecule inhibitors of Hsp90.

Chiosis G, Lucas B, Huezo H, Solit D, Basso A, Rosen N. Chiosis G, et al. Curr Cancer Drug Targets. 2003 Oct;3(5):371-6. doi: 10.2174/1568009033481778. Curr Cancer Drug Targets. 2003. PMID: 14529388 Review.

4

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G. Llauger-Bufi L, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. doi: 10.1016/j.bmcl.2003.08.065. Bioorg Med Chem Lett. 2003. PMID: 14592488

5

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Among authors: chiosis g. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612

6

Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.

Chiosis G. Chiosis G. Expert Opin Ther Targets. 2006 Feb;10(1):37-50. doi: 10.1517/14728222.10.1.37. Expert Opin Ther Targets. 2006. PMID: 16441227 Review.

7

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV. Chiosis G, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. doi: 10.1016/j.bmcl.2006.03.092. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621545

8

Discovery and development of purine-scaffold Hsp90 inhibitors.

Chiosis G. Chiosis G. Curr Top Med Chem. 2006;6(11):1183-91. doi: 10.2174/156802606777812013. Curr Top Med Chem. 2006. PMID: 16842155 Review.

9

Purine-scaffold Hsp90 inhibitors.

Chiosis G, Tao H. Chiosis G, et al. IDrugs. 2006 Nov;9(11):778-82. IDrugs. 2006. PMID: 17096299

10

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.

Chiosis G, Neckers L. Chiosis G, et al. ACS Chem Biol. 2006 Jun 20;1(5):279-84. doi: 10.1021/cb600224w. ACS Chem Biol. 2006. PMID: 17163756 Review.

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