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Chitosan coatings to control release and target tissues for therapeutic delivery.
Jennings JA, Wells CM, McGraw GS, Velasquez Pulgarin DA, Whitaker MD, Pruitt RL, Bumgardner JD. Jennings JA, et al. Ther Deliv. 2015 Jul;6(7):855-71. doi: 10.4155/tde.15.31. Ther Deliv. 2015. PMID: 26228776 Review.
The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery matrices or biomaterials with chitosan offers several advantages in drug delivery, including control of drug releas …
The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery …
Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.
Braim S, Śpiewak K, Brindell M, Heeg D, Alexander C, Monaghan T. Braim S, et al. J Pharm Sci. 2019 Jul;108(7):2438-2446. doi: 10.1016/j.xphs.2019.02.025. Epub 2019 Mar 6. J Pharm Sci. 2019. PMID: 30851342
Different forms of metal-bound bLf were encapsulated in alginate microparticles using an emulsification or internal gelation method. The microparticles were coated with chitosan to control protein release. In vitro drug release studies were cond …
Different forms of metal-bound bLf were encapsulated in alginate microparticles using an emulsification or internal gelation method. The mic …
Therapeutic targeting of chitosan-PEG-folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy.
Kwon OJ, Kang E, Choi JW, Kim SW, Yun CO. Kwon OJ, et al. J Control Release. 2013 Aug 10;169(3):257-65. doi: 10.1016/j.jconrel.2013.03.030. Epub 2013 Apr 4. J Control Release. 2013. PMID: 23562633
In order to circumvent the issues regarding systemic delivery and to increase the safety and efficacy of Ad therapies, the surface of oncolytic Ad was coated with cationic polymer chitosan via ionic crosslinking (Ad/chitosan), after which polyethylene …
In order to circumvent the issues regarding systemic delivery and to increase the safety and efficacy of Ad therapies, the surface of …
Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery.
Cui L, Wang X, Liu Z, Li Z, Bai Z, Lin K, Yang J, Cui Y, Tian F. Cui L, et al. Int J Biol Macromol. 2023 Jun 15;240:124370. doi: 10.1016/j.ijbiomac.2023.124370. Epub 2023 Apr 11. Int J Biol Macromol. 2023. PMID: 37044320
Stimulus-responsive nanomaterials have become a hot spot in controllable drug delivery systems researches owing to their spatiotemporal controllable properties based on the differences between tumor microenvironment and normal tissue. Herein, iron (III …
Stimulus-responsive nanomaterials have become a hot spot in controllable drug delivery systems researches owing to their spati …
Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid.
Xu W, Wang H, Dong L, Zhang P, Mu Y, Cui X, Zhou J, Huo M, Yin T. Xu W, et al. Int J Nanomedicine. 2019 Jun 27;14:4649-4666. doi: 10.2147/IJN.S201110. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31303753 Free PMC article.
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was successfully developed for tumor-specific intracellular rapid delivery of gambogic acid (GA). ...Results: The results of flow cytometry and …
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was succes …
Development and Characterization of Nanoembedded Microparticles for Pulmonary Delivery of Antitubercular Drugs against Experimental Tuberculosis.
Goyal AK, Garg T, Rath G, Gupta UD, Gupta P. Goyal AK, et al. Mol Pharm. 2015 Nov 2;12(11):3839-50. doi: 10.1021/acs.molpharmaceut.5b00016. Epub 2015 Oct 5. Mol Pharm. 2015. PMID: 26436948
In vivo lung distribution study showed that guar gum coated chitosan (GCNP) batches demonstrated prolonged residence at the target site and thereby improve the therapeutic utility of drug with a significant reduction in systemic toxicity. Optimized dru …
In vivo lung distribution study showed that guar gum coated chitosan (GCNP) batches demonstrated prolonged residence at the …
Eudragit-coated chitosan-tripterygium glycoside conjugate microspheres alleviate DSS-induced experimental colitis by inhibiting the TLR4/NF-kappaB signaling pathway.
Xue G, Xiong H, Wang S, Fu Y, Xie Y. Xue G, et al. Biomed Pharmacother. 2023 Feb;158:114194. doi: 10.1016/j.biopha.2022.114194. Epub 2023 Jan 3. Biomed Pharmacother. 2023. PMID: 36916404 Free article.
OBJECTIVE: Tripterygium glycoside (TG) is a fat-soluble extract of Tripterygium wilfordii, with anti-inflammatory properties associated with TLR signaling pathways. This study constructed a targeted delivery system for experimental colitis, namely, eudragit (EuL)- …
OBJECTIVE: Tripterygium glycoside (TG) is a fat-soluble extract of Tripterygium wilfordii, with anti-inflammatory properties associated with …
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers.
Zewail M, Nafee N, Helmy MW, Boraie N. Zewail M, et al. Drug Deliv Transl Res. 2021 Dec;11(6):2496-2519. doi: 10.1007/s13346-021-00992-9. Epub 2021 May 19. Drug Deliv Transl Res. 2021. PMID: 34013458
Nanostructured lipid carriers (NLCs), 200-300 nm, were coated with either chondroitin sulfate (CHS), hyaluronic acid (HA), or chitosan (CS) to provide joint targetability. ...Both HA- and CHS-coated NLCs reduced TNF-alpha level 4-5-fold relative to pos …
Nanostructured lipid carriers (NLCs), 200-300 nm, were coated with either chondroitin sulfate (CHS), hyaluronic acid (HA), or chit …
Formulation and evaluation of floating mucoadhesive alginate beads for targeting Helicobacter pylori.
Adebisi AO, Laity PR, Conway BR. Adebisi AO, et al. J Pharm Pharmacol. 2015 Apr;67(4):511-24. doi: 10.1111/jphp.12345. Epub 2014 Dec 10. J Pharm Pharmacol. 2015. PMID: 25496042
The formulation was modified through addition of oil and coating with chitosan to improve floating, mucoadhesion and modify drug release. KEY FINDINGS: Scanning electron microscopy confirmed the sphericity of the beads with X-ray microtomography showing the t …
The formulation was modified through addition of oil and coating with chitosan to improve floating, mucoadhesion and modify dr …
Efficient mucus permeation and tight junction opening by dissociable "mucus-inert" agent coated trimethyl chitosan nanoparticles for oral insulin delivery.
Liu M, Zhang J, Zhu X, Shan W, Li L, Zhong J, Zhang Z, Huang Y. Liu M, et al. J Control Release. 2016 Jan 28;222:67-77. doi: 10.1016/j.jconrel.2015.12.008. Epub 2015 Dec 11. J Control Release. 2016. PMID: 26686663
Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can efficiently overcome the absorption barriers of mucosa tissue, which consists of not only epithelium but also a blanket of mucus gel. We herein report a novel self-assembled nanop …
Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can efficiently overcome the absorption barriers o …
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