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Chitosan coatings to control release and target tissues for therapeutic delivery.
Jennings JA, Wells CM, McGraw GS, Velasquez Pulgarin DA, Whitaker MD, Pruitt RL, Bumgardner JD. Jennings JA, et al. Ther Deliv. 2015 Jul;6(7):855-71. doi: 10.4155/tde.15.31. Ther Deliv. 2015. PMID: 26228776 Review.
The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery matrices or biomaterials with chitosan offers several advantages in drug delivery, including control of drug releas
The natural biopolymer chitosan has versatile applications in therapeutic delivery. Coating drug delivery
Therapeutic targeting of chitosan-PEG-folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy.
Kwon OJ, Kang E, Choi JW, Kim SW, Yun CO. Kwon OJ, et al. J Control Release. 2013 Aug 10;169(3):257-65. doi: 10.1016/j.jconrel.2013.03.030. Epub 2013 Apr 4. J Control Release. 2013. PMID: 23562633
In order to circumvent the issues regarding systemic delivery and to increase the safety and efficacy of Ad therapies, the surface of oncolytic Ad was coated with cationic polymer chitosan via ionic crosslinking (Ad/chitosan), after which polyethylene …
In order to circumvent the issues regarding systemic delivery and to increase the safety and efficacy of Ad therapies, the surface of …
Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid.
Xu W, Wang H, Dong L, Zhang P, Mu Y, Cui X, Zhou J, Huo M, Yin T. Xu W, et al. Int J Nanomedicine. 2019 Jun 27;14:4649-4666. doi: 10.2147/IJN.S201110. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31303753 Free PMC article.
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was successfully developed for tumor-specific intracellular rapid delivery of gambogic acid (GA). ...Results: The results of flow cytometry and …
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was succes …
Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.
Braim S, Śpiewak K, Brindell M, Heeg D, Alexander C, Monaghan T. Braim S, et al. J Pharm Sci. 2019 Jul;108(7):2438-2446. doi: 10.1016/j.xphs.2019.02.025. Epub 2019 Mar 6. J Pharm Sci. 2019. PMID: 30851342
Different forms of metal-bound bLf were encapsulated in alginate microparticles using an emulsification or internal gelation method. The microparticles were coated with chitosan to control protein release. In vitro drug release studies were cond …
Different forms of metal-bound bLf were encapsulated in alginate microparticles using an emulsification or internal gelation method. The mic …
Development and Characterization of Nanoembedded Microparticles for Pulmonary Delivery of Antitubercular Drugs against Experimental Tuberculosis.
Goyal AK, Garg T, Rath G, Gupta UD, Gupta P. Goyal AK, et al. Mol Pharm. 2015 Nov 2;12(11):3839-50. doi: 10.1021/acs.molpharmaceut.5b00016. Epub 2015 Oct 5. Mol Pharm. 2015. PMID: 26436948
In vivo lung distribution study showed that guar gum coated chitosan (GCNP) batches demonstrated prolonged residence at the target site and thereby improve the therapeutic utility of drug with a significant reduction in systemic toxicity. Optimized dru …
In vivo lung distribution study showed that guar gum coated chitosan (GCNP) batches demonstrated prolonged residence at the …
Efficient mucus permeation and tight junction opening by dissociable "mucus-inert" agent coated trimethyl chitosan nanoparticles for oral insulin delivery.
Liu M, Zhang J, Zhu X, Shan W, Li L, Zhong J, Zhang Z, Huang Y. Liu M, et al. J Control Release. 2016 Jan 28;222:67-77. doi: 10.1016/j.jconrel.2015.12.008. Epub 2015 Dec 11. J Control Release. 2016. PMID: 26686663
We herein report a novel self-assembled nanoparticle (NP) platform for oral delivery of insulin by facilitating the efficient permeation through both of these two barriers. The NP possesses a core composed of insulin and trimethyl chitosan (TMC), and a dissociable " …
We herein report a novel self-assembled nanoparticle (NP) platform for oral delivery of insulin by facilitating the efficient permeat …
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers.
Zewail M, Nafee N, Helmy MW, Boraie N. Zewail M, et al. Drug Deliv Transl Res. 2021 Dec;11(6):2496-2519. doi: 10.1007/s13346-021-00992-9. Epub 2021 May 19. Drug Deliv Transl Res. 2021. PMID: 34013458
Optimized systems ensured convenient gelation time (14-100 s), injectability (5-15 s), formulation-dependent mechanical strength, and extended LEF release up to 51 days. ...Both HA- and CHS-coated NLCs reduced TNF-alpha level 4-5-fold relative to posit …
Optimized systems ensured convenient gelation time (14-100 s), injectability (5-15 s), formulation-dependent mechanical streng …
Formulation and evaluation of floating mucoadhesive alginate beads for targeting Helicobacter pylori.
Adebisi AO, Laity PR, Conway BR. Adebisi AO, et al. J Pharm Pharmacol. 2015 Apr;67(4):511-24. doi: 10.1111/jphp.12345. Epub 2014 Dec 10. J Pharm Pharmacol. 2015. PMID: 25496042
METHODS: Calcium alginate beads were prepared by ionotropic gelation. The formulation was modified through addition of oil and coating with chitosan to improve floating, mucoadhesion and modify drug release. ...CONCLUSIONS: This novel formulation will ensure …
METHODS: Calcium alginate beads were prepared by ionotropic gelation. The formulation was modified through addition of oil and coating
Orally administered mesoporous silica capped with the cucurbit[8]uril complex to combat colitis and improve intestinal homeostasis by targeting the gut microbiota.
Cheng S, Shen H, Zhao S, Zhang Y, Xu H, Wang L, Di B, Xu L, Hu C. Cheng S, et al. Nanoscale. 2020 Jul 23;12(28):15348-15363. doi: 10.1039/d0nr03037f. Nanoscale. 2020. PMID: 32648873
RATIONALE: Inflammatory bowel diseases (IBDs) are still awaiting innovative treatments that can maximize the efficiency of site-specific drug release in the colon while enhancing intestinal homeostasis. METHODS: Herein, we present multilayer-coated mesoporous silica …
RATIONALE: Inflammatory bowel diseases (IBDs) are still awaiting innovative treatments that can maximize the efficiency of site-specific dru …