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Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.
Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA. Amit M, et al. Dev Biol. 2000 Nov 15;227(2):271-8. doi: 10.1006/dbio.2000.9912. Dev Biol. 2000. PMID: 11071754
Generation of hepatocyte-like cells from human embryonic stem cells.
Rambhatla L, Chiu CP, Kundu P, Peng Y, Carpenter MK. Rambhatla L, et al. Cell Transplant. 2003;12(1):1-11. doi: 10.3727/000000003783985179. Cell Transplant. 2003. PMID: 12693659
Enrichment of neurons and neural precursors from human embryonic stem cells.
Carpenter MK, Inokuma MS, Denham J, Mujtaba T, Chiu CP, Rao MS. Carpenter MK, et al. Exp Neurol. 2001 Dec;172(2):383-97. doi: 10.1006/exnr.2001.7832. Exp Neurol. 2001. PMID: 11716562
Chiu, C. P., Harris, M. A. Waknitz, J. Itskovitz-Eldor, and J. A. Thomson. 2000. Dev. Biol. 227: 271-278) and may therefore provide a cell source for cell therapies. hES cells were maintained for over 6 months in vitro (over 100 population doublings) before their ability t
Chiu, C. P., Harris, M. A. Waknitz, J. Itskovitz-Eldor, and J. A. Thomson. 2000. Dev. Biol. 227: 271-278) and may therefore provide a
Human endothelial cell life extension by telomerase expression.
Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, Bronstein A, Chiu CP, Herron GS. Yang J, et al. J Biol Chem. 1999 Sep 10;274(37):26141-8. doi: 10.1074/jbc.274.37.26141. J Biol Chem. 1999. PMID: 10473565
., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. (1998) Science 279, 349-352; Jiang, X., Jimenez, G., Chang, E., Frolkis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A., Wahl, G., Tlsty, T., and Chiu, C....
., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. (1998) Science 279, 349-352; Jiang, X., …
In vitro differentiation capacity of telomerase immortalized human RPE cells.
Rambhatla L, Chiu CP, Glickman RD, Rowe-Rendleman C. Rambhatla L, et al. Invest Ophthalmol Vis Sci. 2002 May;43(5):1622-30. Invest Ophthalmol Vis Sci. 2002. PMID: 11980883
Replicative senescence and cell immortality: the role of telomeres and telomerase.
Chiu CP, Harley CB. Chiu CP, et al. Proc Soc Exp Biol Med. 1997 Feb;214(2):99-106. doi: 10.3181/00379727-214-44075. Proc Soc Exp Biol Med. 1997. PMID: 9034126 Review.
Extension of life-span by introduction of telomerase into normal human cells.
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. Bodnar AG, et al. Science. 1998 Jan 16;279(5349):349-52. doi: 10.1126/science.279.5349.349. Science. 1998. PMID: 9454332
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