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Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects.
Kreutner W, Hey JA, Chiu P, Barnett A. Kreutner W, et al. Arzneimittelforschung. 2000 May;50(5):441-8. doi: 10.1055/s-0031-1300228. Arzneimittelforschung. 2000. PMID: 10858871
Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor.
Vemulapalli S, Watkins RW, Chintala M, Davis H, Ahn HS, Fawzi A, Tulshian D, Chiu P, Chatterjee M, Lin CC, Sybertz EJ. Vemulapalli S, et al. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. doi: 10.1097/00005344-199612000-00018. J Cardiovasc Pharmacol. 1996. PMID: 8961086
SCH 51866 (1-10 mg/kg, p.o. twice daily) but not E4021 (3-30 mg/kg, p.o twice daily) inhibited neointima formation in the carotid arteries of spontaneously hypertensive rats (SHRs) subjected to balloon angioplasty. Moreover, SCH 51866 (0.3-10 mg/kg, p.o.) eli …
SCH 51866 (1-10 mg/kg, p.o. twice daily) but not E4021 (3-30 mg/kg, p.o twice daily) inhibited neointima formation in the caro …
Disparate effects of phosphoramidon on blood pressure in SHR and DOCA-salt hypertensive rats.
Vemulapalli S, Watkins RW, Brown A, Cook J, Bernardino V, Chiu PJ. Vemulapalli S, et al. Life Sci. 1993;53(10):783-93. doi: 10.1016/0024-3205(93)90500-3. Life Sci. 1993. PMID: 8355566
SCH 32615 (100 mg/kg, i.v.) over 5 min followed by a sustained infusion of 1.0 mg/kg/min for 2 hr also reduced BP by 49 +/- 7 mmHg (P < .05) in DOCA-salt rats. ...
SCH 32615 (100 mg/kg, i.v.) over 5 min followed by a sustained infusion of 1.0 mg/kg/min for 2 hr also reduced BP by 49 +/- 7 mmHg (P
Characterization of in vitro and in vivo platelet responses to thrombin and thrombin receptor-activating peptides in guinea pigs.
Chiu PJ, Tetzloff GG, Foster C, Chintala M, Sybertz EJ. Chiu PJ, et al. Eur J Pharmacol. 1997 Feb 19;321(1):129-35. doi: 10.1016/s0014-2999(96)00931-4. Eur J Pharmacol. 1997. PMID: 9083795
Therefore, guinea pigs anesthetized with Inactin (90 mg/kg i.p.) were used to assess in vivo activities of thrombin and thrombin receptor-activating peptides (TRAPs) using 111 In-labeled platelets and a microcomputer-based system. ...Responses of similar magnitude were ind …
Therefore, guinea pigs anesthetized with Inactin (90 mg/kg i.p.) were used to assess in vivo activities of thrombin and thrombin rece …
Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor.
Watkins RW, Vemulapalli S, Chiu PJ, Foster C, Smith EM, Neustadt B, Haslanger M, Sybertz EJ. Watkins RW, et al. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. doi: 10.1093/ajh/6.5.357. Am J Hypertens. 1993. PMID: 8512660
Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats.
Chintala MS, Chiu PJ, Vemulapalli S, Watkins RW, Sybertz EJ. Chintala MS, et al. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):305-10. doi: 10.1007/BF00169160. Naunyn Schmiedebergs Arch Pharmacol. 1993. PMID: 8232607
Atrial natriuretic factor-potentiating and antihypertensive activity of SCH 34826. An orally active neutral metalloendopeptidase inhibitor.
Sybertz EJ, Chiu PJ, Vemulapalli S, Watkins R, Haslanger MF. Sybertz EJ, et al. Hypertension. 1990 Feb;15(2):152-61. doi: 10.1161/01.hyp.15.2.152. Hypertension. 1990. PMID: 2154404
SCH 34826 significantly reduced blood pressure in the conscious deoxycorticosterone acetate-salt hypertensive rat, at doses of 90 mg/kg s.c. (-35 +/- 12 mm Hg), 10 mg/kg p.o. (-30 +/- 7 mm Hg), and 90 mg/kg p.o. (-45 +/- 6 mm Hg). ...The renal excretion of atrial na …
SCH 34826 significantly reduced blood pressure in the conscious deoxycorticosterone acetate-salt hypertensive rat, at doses of 90 mg/kg s.c. …
Phosphoramidon abolishes the increases in endothelin-1 release induced by ischemia-hypoxia in isolated perfused guinea pig lungs.
Vemulapalli S, Rivelli M, Chiu PJ, del Prado M, Hey JA. Vemulapalli S, et al. J Pharmacol Exp Ther. 1992 Sep;262(3):1062-9. J Pharmacol Exp Ther. 1992. PMID: 1527713
Guinea pig lungs subjected to 15 min I/H followed by reperfusion and reventilation significantly (P less than .05) augmented ET-1 release from 14.1 +/- 2.7 to 30.4 +/- 5.6, 27.3 +/- 4.0 and 28.0 +/- 5.0 pg/g of dry weight of lung at 15, 30 and 45 min after I/H, respectivel …
Guinea pig lungs subjected to 15 min I/H followed by reperfusion and reventilation significantly (P less than .05) augmented ET-1 rel …
Sympathoadrenal stimulation, not endothelin, plays a role in acute pressor response to cyclosporine in anesthetized rats.
Chiu PJ, Vemulapalli S, Sabin C, Rivelli M, Bernardino V, Sybertz EJ. Chiu PJ, et al. J Pharmacol Exp Ther. 1992 Jun;261(3):994-9. J Pharmacol Exp Ther. 1992. PMID: 1602404
In intact rats, pretreatment with reserpine (5 mg/kg, i.p.) or hexamethonium (10 mg/kg, i.v.) greatly blunted the pressor responses to CS (40 mg/kg) (7 +/- 3 and 11 +/- 2 mm Hg, respectively). ...
In intact rats, pretreatment with reserpine (5 mg/kg, i.p.) or hexamethonium (10 mg/kg, i.v.) greatly blunted the pressor responses t …
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