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4,853 results

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Page 1
Clinical pharmacokinetics of chlordiazepoxide.
Greenblatt DJ, Shader RI, MacLeod SM, Sellers EM. Greenblatt DJ, et al. Clin Pharmacokinet. 1978 Sep-Oct;3(5):381-94. doi: 10.2165/00003088-197803050-00004. Clin Pharmacokinet. 1978. PMID: 359214 Review.
Chlordiazepoxide was the first benzodiazepine derivative made available for clinical use. The metabolic pathway of chlordiazepoxide is complex, since the drug is biotransformed into a succession of pharmacologically active products: desmethylchlordiazepoxide, demoxe …
Chlordiazepoxide was the first benzodiazepine derivative made available for clinical use. The metabolic pathway of chlordiazepoxid …
Is chlordiazepoxide the rational choice among benzodiazepines?
Baskin SI, Esdale A. Baskin SI, et al. Pharmacotherapy. 1982 Mar-Apr;2(2):110-9. doi: 10.1002/j.1875-9114.1982.tb03181.x. Pharmacotherapy. 1982. PMID: 6152590 Review.
There is evidence that the antianxiety effect of chlordiazepoxide is related to the appearance of its two active metabolites, which may explain the observed delay in its onset of action. When chlordiazepoxide's reduced clearance in the elderly and in patients with l …
There is evidence that the antianxiety effect of chlordiazepoxide is related to the appearance of its two active metabolites, which m …
Effects of chlordiazepoxide on pausing during rich-to-lean transitions.
Langford JS, Batchelder SR, Haste DA, Thuman EP, Pitts RC, Hughes CE. Langford JS, et al. J Exp Anal Behav. 2021 Jul;116(1):3-20. doi: 10.1002/jeab.703. Epub 2021 Jun 18. J Exp Anal Behav. 2021. PMID: 34144632
Intermediate doses (3.0-10.0 mg/kg) of chlordiazepoxide differentially decreased median pauses during rich-to-lean transitions. Relatively small decreases in pauses occurred during lean-to-lean and rich-to-rich transitions. Effects of chlordiazepoxide on pausing occ …
Intermediate doses (3.0-10.0 mg/kg) of chlordiazepoxide differentially decreased median pauses during rich-to-lean transitions. Relat …
Alcohol-chlordiazepoxide interaction.
Chan AW, Greizerstein HB, Strauss W. Chan AW, et al. Pharmacol Biochem Behav. 1982 Jul;17(1):141-5. doi: 10.1016/0091-3057(82)90276-3. Pharmacol Biochem Behav. 1982. PMID: 7122659
The effects of chlordiazepoxide (CDP) or its N-demethyl metabolite (NDCDP) on ethanol-induced sleep time were investigated. ...
The effects of chlordiazepoxide (CDP) or its N-demethyl metabolite (NDCDP) on ethanol-induced sleep time were investigated. ...
The discovery of chlordiazepoxide and the clinical introduction of benzodiazepines: half a century of anxiolytic drugs.
López-Muñoz F, Alamo C, García-García P. López-Muñoz F, et al. J Anxiety Disord. 2011 May;25(4):554-62. doi: 10.1016/j.janxdis.2011.01.002. Epub 2011 Jan 22. J Anxiety Disord. 2011. PMID: 21315551 Review.
The clinical introduction of chlordiazepoxide half a century ago was one of the major breakthroughs in the history of psychopharmacology, as it opened the door for the benzodiazepine saga, the pharmacological family par excellence in the treatment of anxiety disorders. Thi …
The clinical introduction of chlordiazepoxide half a century ago was one of the major breakthroughs in the history of psychopharmacol …
Chlordiazepoxide and pentobarbital as tranquilizers for cowbirds and coturnix quail.
Peek JM. Peek JM. J Am Vet Med Assoc. 1966 Oct 1;149(7):950-2. J Am Vet Med Assoc. 1966. PMID: 22413210 Clinical Trial.
The effects of ad libitum ingestion of chlordiazepoxide and sodium pentobarbital on penned cowbirds and coturnix quail were compared. ...No deaths occurred among birds given chlordiazepoxide, whereas 4 quail and 1 cowbird died from sodium pentobarbital ingestion....
The effects of ad libitum ingestion of chlordiazepoxide and sodium pentobarbital on penned cowbirds and coturnix quail were compared. …
Radioimmunoassay of chlordiazepoxide in plasma.
Dixon WR, Earley J, Postma E. Dixon WR, et al. J Pharm Sci. 1975 Jun;64(6):937-9. doi: 10.1002/jps.2600640607. J Pharm Sci. 1975. PMID: 1133745
The radioimmunoassay allows for the specific determination of chlordiazepoxide directly in plasma without extraction and was compared with a differential spectrofluorometric assay for chlordiazepoxide. Both methods gave satisfactory agreement for the plasma levels o …
The radioimmunoassay allows for the specific determination of chlordiazepoxide directly in plasma without extraction and was compared …
4,853 results