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On- and off-target effects of paired CRISPR-Cas nickase in primary human cells.
Klermund J, Rhiel M, Kocher T, Chmielewski KO, Bischof J, Andrieux G, El Gaz M, Hainzl S, Boerries M, Cornu TI, Koller U, Cathomen T. Klermund J, et al. Among authors: chmielewski ko. Mol Ther. 2024 Mar 7:S1525-0016(24)00147-3. doi: 10.1016/j.ymthe.2024.03.006. Online ahead of print. Mol Ther. 2024. PMID: 38459694 Free article.
CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells.
Hammad R, Alzubi J, Rhiel M, Chmielewski KO, Mosti L, Rositzka J, Heugel M, Lawrenz J, Pennucci V, Gläser B, Fischer J, Schambach A, Moritz T, Lachmann N, Cornu TI, Mussolino C, Schäfer R, Cathomen T. Hammad R, et al. Among authors: chmielewski ko. Int J Mol Sci. 2024 Jan 12;25(2):985. doi: 10.3390/ijms25020985. Int J Mol Sci. 2024. PMID: 38256061 Free PMC article.
Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1.
Torella L, Klermund J, Bilbao-Arribas M, Tamayo I, Andrieux G, Chmielewski KO, Vales A, Olagüe C, Moreno-Luqui D, Raimondi I, Abad A, Torrens-Baile J, Salido E, Huarte M, Hernaez M, Boerries M, Cathomen T, Zabaleta N, Gonzalez-Aseguinolaza G. Torella L, et al. Among authors: chmielewski ko. EMBO Mol Med. 2024 Jan;16(1):112-131. doi: 10.1038/s44321-023-00008-8. Epub 2024 Jan 5. EMBO Mol Med. 2024. PMID: 38182795 Free PMC article.
38 results