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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Choi CS, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. doi: 10.1073/pnas.0706794104. Epub 2007 Oct 8. Proc Natl Acad Sci U S A. 2007. PMID: 17923673 Free PMC article.
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI. Choi CS, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. doi: 10.1073/pnas.0810339105. Epub 2008 Dec 9. Proc Natl Acad Sci U S A. 2008. PMID: 19066218 Free PMC article.
Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.
Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Lee HY, et al. Among authors: choi cs. Diabetologia. 2014 Jun;57(6):1232-41. doi: 10.1007/s00125-014-3212-1. Epub 2014 Apr 11. Diabetologia. 2014. PMID: 24718953 Free PMC article.
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI. Choi CS, et al. J Biol Chem. 2007 Aug 3;282(31):22678-88. doi: 10.1074/jbc.M704213200. Epub 2007 May 27. J Biol Chem. 2007. PMID: 17526931 Free article.
451 results