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A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.
Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G 3rd, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas CJ. Jiang JK, et al. Among authors: choi ws. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53. doi: 10.1016/j.bmcl.2013.12.122. Epub 2014 Jan 8. Bioorg Med Chem Lett. 2014. PMID: 24461295 Free PMC article.
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Zhu J, et al. Among authors: choi ws. Sci Transl Med. 2012 Mar 14;4(125):125ra32. doi: 10.1126/scitranslmed.3003576. Sci Transl Med. 2012. PMID: 22422993 Free PMC article.
Strategies for Overcoming Immune Evasion in Bladder Cancer.
Shin J, Park JW, Kim SY, Lee JH, Choi WS, Kim HS. Shin J, et al. Among authors: choi ws. Int J Mol Sci. 2024 Mar 7;25(6):3105. doi: 10.3390/ijms25063105. Int J Mol Sci. 2024. PMID: 38542078 Free PMC article. Review.
1,433 results