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Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.
Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. Boettler T, et al. Among authors: choi ys. J Immunol. 2013 Nov 15;191(10):5026-35. doi: 10.4049/jimmunol.1300013. Epub 2013 Oct 7. J Immunol. 2013. PMID: 24101548 Free PMC article.
STAT5 is a potent negative regulator of TFH cell differentiation.
Johnston RJ, Choi YS, Diamond JA, Yang JA, Crotty S. Johnston RJ, et al. Among authors: choi ys. J Exp Med. 2012 Feb 13;209(2):243-50. doi: 10.1084/jem.20111174. Epub 2012 Jan 23. J Exp Med. 2012. PMID: 22271576 Free PMC article.
The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.
Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Tucker HO, Erikson J, Hu H. Wang H, et al. Among authors: choi ys. Nat Immunol. 2014 Jul;15(7):667-75. doi: 10.1038/ni.2890. Epub 2014 May 25. Nat Immunol. 2014. PMID: 24859450 Free PMC article.
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