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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2004 1
2005 1
2009 1
2010 3
2012 1
2015 1
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2018 3
2019 1
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2024 0

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17 results

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Page 1
Odevixibat: First Approval.
Deeks ED. Deeks ED. Drugs. 2021 Oct;81(15):1781-1786. doi: 10.1007/s40265-021-01594-y. Drugs. 2021. PMID: 34499340 Free PMC article. Review.
Odevixibat (Bylvay) is a small molecule inhibitor of the ileal bile acid transporter being developed by Albireo Pharma, Inc. for the treatment of various cholestatic diseases, including progressive familial intrahepatic cholestasis (PFIC). In July 2021 …
Odevixibat (Bylvay) is a small molecule inhibitor of the ileal bile acid transporter being developed by Albireo Pharma, Inc. for the treatme …
The Cholangiopathies.
Lazaridis KN, LaRusso NF. Lazaridis KN, et al. Mayo Clin Proc. 2015 Jun;90(6):791-800. doi: 10.1016/j.mayocp.2015.03.017. Epub 2015 May 6. Mayo Clin Proc. 2015. PMID: 25957621 Free PMC article. Review.
We also present the recent progress made in understanding the pathogenesis of and how this knowledge has influenced therapies for the 6 common cholangiopathies-primary biliary cirrhosis, primary sclerosing cholangitis, cystic fibrosis involving the liver, biliary at …
We also present the recent progress made in understanding the pathogenesis of and how this knowledge has influenced therapies for the …
Clinical and genetic characterization of pediatric patients with progressive familial intrahepatic cholestasis type 3 (PFIC3): identification of 14 novel ABCB4 variants and review of the literatures.
Chen R, Yang FX, Tan YF, Deng M, Li H, Xu Y, Ouyang WX, Song YZ. Chen R, et al. Orphanet J Rare Dis. 2022 Dec 22;17(1):445. doi: 10.1186/s13023-022-02597-y. Orphanet J Rare Dis. 2022. PMID: 36550572 Free PMC article. Review.
BACKGROUND: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is an autosomal recessive disease caused by pathogenic variants of the gene ABCB4. ...Among all the 95 PFIC3 cases, hepatomegaly was observed in 85.3% (81/95), pruritus in …
BACKGROUND: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is an autosomal recessive disease
Progressive familial intrahepatic cholestasis.
Hori T, Nguyen JH, Uemoto S. Hori T, et al. Hepatobiliary Pancreat Dis Int. 2010 Dec;9(6):570-8. Hepatobiliary Pancreat Dis Int. 2010. PMID: 21134824 Review.
BACKGROUND: Three types of progressive familial intrahepatic cholestasis (PFIC) have been identified, but their etiologies include unknown mechanisms. DATA SOURCES: A PubMed search on "progressive familial intrahepatic cholestas
BACKGROUND: Three types of progressive familial intrahepatic cholestasis (PFIC) have been identified, but their …
Progressive familial intrahepatic cholestasis.
Jacquemin E. Jacquemin E. J Gastroenterol Hepatol. 1999 Jun;14(6):594-9. doi: 10.1046/j.1440-1746.1999.01921.x. J Gastroenterol Hepatol. 1999. PMID: 10385071 Review.
Progressive familial intrahepatic cholestasis (PFIC), also known as Byler disease, is an inherited disorder of childhood in which cholestasis of hepatocellular origin often presents in the neonatal period and leads to death from liver fai
Progressive familial intrahepatic cholestasis (PFIC), also known as Byler disease, is an inherited disord
Genetic determinants of cholangiopathies: Molecular and systems genetics.
Reichert MC, Hall RA, Krawczyk M, Lammert F. Reichert MC, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1484-1490. doi: 10.1016/j.bbadis.2017.07.029. Epub 2017 Jul 27. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28757171 Free article. Review.
Their spectrum ranges from fairly benign conditions as, for example, benign recurrent intrahepatic cholestasis to low-phospholipid associated cholelithiasis and progressive familial intrahepatic cholestasis (PFIC). ...In recent years our …
Their spectrum ranges from fairly benign conditions as, for example, benign recurrent intrahepatic cholestasis to low-phosphol …
Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters.
Harris MJ, Le Couteur DG, Arias IM. Harris MJ, et al. J Gastroenterol Hepatol. 2005 Jun;20(6):807-17. doi: 10.1111/j.1440-1746.2005.03743.x. J Gastroenterol Hepatol. 2005. PMID: 15946126 Review.
Progressive familial intrahepatic cholestasis types 1, 2 and 3 are childhood diseases of the liver. ...These genetic disorders have significantly helped to unravel the basic mechanisms of the canalicular bile transport processes. Progressive
Progressive familial intrahepatic cholestasis types 1, 2 and 3 are childhood diseases of the liver. ...These gen
Progressive intrahepatic cholestasis: mechanisms, diagnosis and therapy.
Shneider BL. Shneider BL. Pediatr Transplant. 2004 Dec;8(6):609-12. doi: 10.1111/j.1399-3046.2004.00240.x. Pediatr Transplant. 2004. PMID: 15598335 Review.
Progressive intrahepatic cholestasis (PIHC, also known as progressive familial intrahepatic cholestasis) is a general term encompassing a devastating group of illnesses manifest by severe morbidity and potential mortality. ...The m
Progressive intrahepatic cholestasis (PIHC, also known as progressive familial intrahepatic cho
[Importance of Reverse Translational Research (rTR)].
Sugiyama Y. Sugiyama Y. Yakugaku Zasshi. 2017;137(6):673-679. doi: 10.1248/yakushi.16-00250-1. Yakugaku Zasshi. 2017. PMID: 28566572 Free article. Review. Japanese.
This is true for medications and therapies, in addition to problems inherent in an underlying disease. However, the recent development of modeling and metric methods makes it possible to estimate the relationship between side effects and various factors to explain inter-in …
This is true for medications and therapies, in addition to problems inherent in an underlying disease. However, the recent developmen …
Liver diseases related to MDR3 (ABCB4) gene deficiency.
Gonzales E, Davit-Spraul A, Baussan C, Buffet C, Maurice M, Jacquemin E. Gonzales E, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14(11):4242-56. doi: 10.2741/3526. Front Biosci (Landmark Ed). 2009. PMID: 19273348 Free article. Review.
Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in …
Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in bilia …
17 results