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MtDNA mutations in aging and apoptosis.
Chomyn A, Attardi G. Chomyn A, et al. Biochem Biophys Res Commun. 2003 May 9;304(3):519-29. doi: 10.1016/s0006-291x(03)00625-9. Biochem Biophys Res Commun. 2003. PMID: 12729587 Review.
MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Hashimoto M, Bacman SR, Peralta S, Falk MJ, Chomyn A, Chan DC, Williams SL, Moraes CT. Hashimoto M, et al. Among authors: chomyn a. Mol Ther. 2015 Oct;23(10):1592-9. doi: 10.1038/mt.2015.126. Epub 2015 Jul 10. Mol Ther. 2015. PMID: 26159306 Free PMC article.
Genetic and functional analysis of mitochondrial DNA-encoded complex I genes.
Bai Y, Hu P, Park JS, Deng JH, Song X, Chomyn A, Yagi T, Attardi G. Bai Y, et al. Among authors: chomyn a. Ann N Y Acad Sci. 2004 Apr;1011:272-83. doi: 10.1007/978-3-662-41088-2_26. Ann N Y Acad Sci. 2004. PMID: 15126303
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Chen H, et al. Among authors: chomyn a. Cell. 2010 Apr 16;141(2):280-9. doi: 10.1016/j.cell.2010.02.026. Cell. 2010. PMID: 20403324 Free PMC article.
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G. Iwata N, et al. Among authors: chomyn a. Mitochondrion. 2007 Jul;7(4):267-72. doi: 10.1016/j.mito.2007.03.001. Epub 2007 Mar 12. Mitochondrion. 2007. PMID: 17452024
Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis.
Duan S, Hajek P, Lin C, Shin SK, Attardi G, Chomyn A. Duan S, et al. J Biol Chem. 2003 Jan 10;278(2):1346-53. doi: 10.1074/jbc.M209269200. Epub 2002 Oct 25. J Biol Chem. 2003. PMID: 12403774
This interpretation was confirmed by another surprising finding, namely that, in staurosporine-treated 143B.TK(-) cells permeabilized with digitonin at a concentration not affecting the mitochondrial membranes in naive cells, the outer mitochondrial membrane loses its inte …
This interpretation was confirmed by another surprising finding, namely that, in staurosporine-treated 143B.TK(-) cells permeabilized with d …
Platelet-mediated transformation of human mitochondrial DNA-less cells.
Chomyn A. Chomyn A. Methods Enzymol. 1996;264:334-9. doi: 10.1016/s0076-6879(96)64031-2. Methods Enzymol. 1996. PMID: 8965706 No abstract available.
In vivo labeling and analysis of human mitochondrial translation products.
Chomyn A. Chomyn A. Methods Enzymol. 1996;264:197-211. doi: 10.1016/s0076-6879(96)64020-8. Methods Enzymol. 1996. PMID: 8965693 No abstract available.
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