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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Hashimoto M, Bacman SR, Peralta S, Falk MJ, Chomyn A, Chan DC, Williams SL, Moraes CT. Hashimoto M, et al. Among authors: chomyn a. Mol Ther. 2015 Oct;23(10):1592-9. doi: 10.1038/mt.2015.126. Epub 2015 Jul 10. Mol Ther. 2015. PMID: 26159306 Free PMC article.
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Chen H, et al. Among authors: chomyn a. Cell. 2010 Apr 16;141(2):280-9. doi: 10.1016/j.cell.2010.02.026. Cell. 2010. PMID: 20403324 Free PMC article.
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G. Iwata N, et al. Among authors: chomyn a. Mitochondrion. 2007 Jul;7(4):267-72. doi: 10.1016/j.mito.2007.03.001. Epub 2007 Mar 12. Mitochondrion. 2007. PMID: 17452024
Disruption of fusion results in mitochondrial heterogeneity and dysfunction.
Chen H, Chomyn A, Chan DC. Chen H, et al. Among authors: chomyn a. J Biol Chem. 2005 Jul 15;280(28):26185-92. doi: 10.1074/jbc.M503062200. Epub 2005 May 17. J Biol Chem. 2005. PMID: 15899901 Free article.
MtDNA mutations in aging and apoptosis.
Chomyn A, Attardi G. Chomyn A, et al. Biochem Biophys Res Commun. 2003 May 9;304(3):519-29. doi: 10.1016/s0006-291x(03)00625-9. Biochem Biophys Res Commun. 2003. PMID: 12729587 Review.
Platelet-mediated transformation of human mitochondrial DNA-less cells.
Chomyn A. Chomyn A. Methods Enzymol. 1996;264:334-9. doi: 10.1016/s0076-6879(96)64031-2. Methods Enzymol. 1996. PMID: 8965706 No abstract available.
In vivo labeling and analysis of human mitochondrial translation products.
Chomyn A. Chomyn A. Methods Enzymol. 1996;264:197-211. doi: 10.1016/s0076-6879(96)64020-8. Methods Enzymol. 1996. PMID: 8965693 No abstract available.
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