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Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.
Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB. Kutzler MA, et al. Among authors: choo dk. J Immunol. 2005 Jul 1;175(1):112-23. doi: 10.4049/jimmunol.175.1.112. J Immunol. 2005. PMID: 15972637
HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells.
Muthumani K, Shedlock DJ, Choo DK, Fagone P, Kawalekar OU, Goodman J, Bian CB, Ramanathan AA, Atman P, Tebas P, Chattergoon MA, Choo AY, Weiner DB. Muthumani K, et al. Among authors: choo dk. J Immunol. 2011 Sep 15;187(6):2932-43. doi: 10.4049/jimmunol.1100594. Epub 2011 Aug 19. J Immunol. 2011. PMID: 21856939 Free PMC article.
DNA vaccination in immunotherapy of cancer.
Choo AY, Choo DK, Kim JJ, Weiner DB. Choo AY, et al. Among authors: choo dk. Cancer Treat Res. 2005;123:137-56. doi: 10.1007/0-387-27545-2_6. Cancer Treat Res. 2005. PMID: 16211869 Review. No abstract available.
Synthetic DNA vaccine strategies against persistent viral infections.
Villarreal DO, Talbott KT, Choo DK, Shedlock DJ, Weiner DB. Villarreal DO, et al. Among authors: choo dk. Expert Rev Vaccines. 2013 May;12(5):537-54. doi: 10.1586/erv.13.33. Expert Rev Vaccines. 2013. PMID: 23659301 Free PMC article. Review.
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Yan J, Tingey C, Lyde R, Gorham TC, Choo DK, Muthumani A, Myles D, Weiner LP, Kraynyak KA, Reuschel EL, Finkel TH, Kim JJ, Sardesai NY, Ugen KE, Muthumani K, Weiner DB. Yan J, et al. Among authors: choo dk. Cancer Gene Ther. 2014 Dec;21(12):507-17. doi: 10.1038/cgt.2014.56. Epub 2014 Nov 14. Cancer Gene Ther. 2014. PMID: 25394503