Chopra R - Search Results

1

Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.

Chopra R, Wasserman AH, Pulst SM, De Zeeuw CI, Shakkottai VG. Chopra R, et al. Hum Mol Genet. 2018 Apr 15;27(8):1396-1410. doi: 10.1093/hmg/ddy050. Hum Mol Genet. 2018. PMID: 29432535 Free PMC article.

2

Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia.

Chopra R, Shakkottai VG. Chopra R, et al. Future Neurol. 2014 Mar 1;9(2):187-196. doi: 10.2217/fnl.14.6. Future Neurol. 2014. PMID: 25221437 Free PMC article.

3

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.

Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. Dell'Orco JM, et al. Among authors: chopra r. J Neurosci. 2015 Aug 12;35(32):11292-307. doi: 10.1523/JNEUROSCI.1357-15.2015. J Neurosci. 2015. PMID: 26269637 Free PMC article.

4

Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1.

Chopra R, Bushart DD, Shakkottai VG. Chopra R, et al. PLoS One. 2018 May 30;13(5):e0198040. doi: 10.1371/journal.pone.0198040. eCollection 2018. PLoS One. 2018. PMID: 29847609 Free PMC article.

5

MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.

Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, Oro AE. Brown AS, et al. Among authors: chopra r. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12407-E12416. doi: 10.1073/pnas.1816177115. Epub 2018 Dec 7. Proc Natl Acad Sci U S A. 2018. PMID: 30530649 Free PMC article.

6

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.

Chopra R, Bushart DD, Cooper JP, Yellajoshyula D, Morrison LM, Huang H, Handler HP, Man LJ, Dansithong W, Scoles DR, Pulst SM, Orr HT, Shakkottai VG. Chopra R, et al. Hum Mol Genet. 2020 Nov 25;29(19):3249-3265. doi: 10.1093/hmg/ddaa212. Hum Mol Genet. 2020. PMID: 32964235 Free PMC article.

7

The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.

Chopra R, Shakkottai VG. Chopra R, et al. Neurotherapeutics. 2014 Oct;11(4):751-63. doi: 10.1007/s13311-014-0289-7. Neurotherapeutics. 2014. PMID: 24986674 Free PMC article. Review.

8

Targeting potassium channels to treat cerebellar ataxia.

Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. Bushart DD, et al. Among authors: chopra r. Ann Clin Transl Neurol. 2018 Jan 22;5(3):297-314. doi: 10.1002/acn3.527. eCollection 2018 Mar. Ann Clin Transl Neurol. 2018. PMID: 29560375 Free PMC article.

9

Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.

McLoughlin HS, Moore LR, Chopra R, Komlo R, McKenzie M, Blumenstein KG, Zhao H, Kordasiewicz HB, Shakkottai VG, Paulson HL. McLoughlin HS, et al. Among authors: chopra r. Ann Neurol. 2018 Jul;84(1):64-77. doi: 10.1002/ana.25264. Epub 2018 Aug 6. Ann Neurol. 2018. PMID: 29908063 Free PMC article.

10

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.

Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP. Schultz ML, et al. Among authors: chopra r. Nat Commun. 2018 Sep 10;9(1):3671. doi: 10.1038/s41467-018-06115-2. Nat Commun. 2018. PMID: 30202070 Free PMC article.

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