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62 results

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Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway.
Jiang P, Chen L, Sun J, Li J, Xu J, Liu W, Feng F, Qu W. Jiang P, et al. J Pharmacol Sci. 2019 Feb;139(2):105-111. doi: 10.1016/j.jphs.2018.12.003. Epub 2018 Dec 22. J Pharmacol Sci. 2019. PMID: 30642751 Free article.
Recent studies suggested that Chotosan has ameliorative effects on vascular dementia through antioxidative pathways. ...Chotosan may serve as a potential candidate and promising Nrf2 activator for treating vascular dementia....
Recent studies suggested that Chotosan has ameliorative effects on vascular dementia through antioxidative pathways. ...Chotosan
Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence.
Matsumoto K, Zhao Q, Niu Y, Fujiwara H, Tanaka K, Sasaki-Hamada S, Oka J. Matsumoto K, et al. J Pharmacol Sci. 2013;122(4):257-69. doi: 10.1254/jphs.13r03cr. Epub 2013 Jul 25. J Pharmacol Sci. 2013. PMID: 23883485 Free article. Review.
Clinical evidence has demonstrated the potential usefulness of chotosan (CTS) and yokukansan (YKS), traditional herbal formulations called Kampo medicines, in the treatment of cognitive disturbance and BPSD in dementia patients, although the indications targeted by CTS and …
Clinical evidence has demonstrated the potential usefulness of chotosan (CTS) and yokukansan (YKS), traditional herbal formulations c …
Chotosan, a Kampo formula, ameliorates hippocampal LTD and cognitive deficits in juvenile-onset diabetes rats.
Sasaki-Hamada S, Tamaki K, Otsuka H, Ueno T, Sacai H, Niu Y, Matsumoto K, Oka J. Sasaki-Hamada S, et al. J Pharmacol Sci. 2014;124(2):192-200. doi: 10.1254/jphs.13179fp. Epub 2014 Jan 29. J Pharmacol Sci. 2014. PMID: 24476927 Free article.
Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset diabetes mellitus (JDM) rats. In this study, we investigated the effect of chotosan (CTS), a traditional herbal formula called a Kampo medicine, which h …
Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset diabetes mellitus ( …
Chotosan improves Abeta1-42-induced cognitive impairment and neuroinflammatory and apoptotic responses through the inhibition of TLR-4/NF-kappaB signaling in mice.
Chen L, Hu L, Zhao J, Hong H, Feng F, Qu W, Liu W. Chen L, et al. J Ethnopharmacol. 2016 Sep 15;191:398-407. doi: 10.1016/j.jep.2016.03.038. Epub 2016 Mar 16. J Ethnopharmacol. 2016. PMID: 26994819
ETHNOPHARMACOLOGICAL RELEVANCE: Recently, the focus on neuroinflammation is intensified as its complex pathophysiological role has emerged in multiple central nervous system(CNS) disorders. Chotosan (CTS), known as a traditional herbal formula, is often utilized to treat r …
ETHNOPHARMACOLOGICAL RELEVANCE: Recently, the focus on neuroinflammation is intensified as its complex pathophysiological role has emerged i …
Preventive effect of chotosan, a Kampo medicine, on transient ischemia-induced learning deficit is mediated by stimulation of muscarinic M1 but not nicotinic receptor.
Zhao Q, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Zhao Q, et al. Biol Pharm Bull. 2005 Oct;28(10):1873-8. doi: 10.1248/bpb.28.1873. Biol Pharm Bull. 2005. PMID: 16204938 Free article.
Chotosan administration 1 h before T2VO operation prevented learning impairment. The extract of Uncaria, a major constituent of chotosan, also had a protective effect on learning impairment in T2VO mice, whereas Uncaria-free chotosan had no beneficial effect
Chotosan administration 1 h before T2VO operation prevented learning impairment. The extract of Uncaria, a major constituent of ch
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.
Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, Yokozawa T. Zhao Q, et al. BMC Complement Altern Med. 2012 Oct 20;12:188. doi: 10.1186/1472-6882-12-188. BMC Complement Altern Med. 2012. PMID: 23082896 Free PMC article.
To obtain a better understanding of the anti-dementia effect of chotosan (CTS), a Kampo formula, we investigated its effects on cognitive and emotional deficits of type 2 diabetic db/db mice and putative mechanism(s) underlying the effects. ...
To obtain a better understanding of the anti-dementia effect of chotosan (CTS), a Kampo formula, we investigated its effects on cogni …
Protective effects of a Chotosan Fraction and its active components on beta-amyloid-induced neurotoxicity.
Wei M, Chen L, Liu J, Zhao J, Liu W, Feng F. Wei M, et al. Neurosci Lett. 2016 Mar 23;617:143-9. doi: 10.1016/j.neulet.2016.02.019. Epub 2016 Feb 12. Neurosci Lett. 2016. PMID: 26876445
Chotosan (CTS) is a traditional Kampo prescription used to treat chronic headache and hypertension. ...
Chotosan (CTS) is a traditional Kampo prescription used to treat chronic headache and hypertension. ...
Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glioma cells.
Obi R, Tohda M, Zhao Q, Obi N, Hori H, Murakami Y, Goto H, Shimada Y, Ochiai H, Matsumoto K. Obi R, et al. Biol Pharm Bull. 2007 Dec;30(12):2250-6. doi: 10.1248/bpb.30.2250. Biol Pharm Bull. 2007. PMID: 18057707 Free article.
The effect of chotosan was reversed by Ro 31-8220 (1 muM), a selective protein kinase C (PKC) inhibitor, but not by H-89 (10 muM), a selective protein kinase A (PKA) inhibitor. These findings suggest that the upregulatory effect of chotosan on M-CSF mRNA expression …
The effect of chotosan was reversed by Ro 31-8220 (1 muM), a selective protein kinase C (PKC) inhibitor, but not by H-89 (10 muM), a …
Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.
Zhao Q, Yokozawa T, Tsuneyama K, Tanaka K, Miyata T, Shibahara N, Matsumoto K. Zhao Q, et al. Chin Med. 2011 Sep 23;6:33. doi: 10.1186/1749-8546-6-33. Chin Med. 2011. PMID: 21943225 Free PMC article.
BACKGROUND: Chotosan (CTS, Diaoteng San), a Kampo medicine (ie Chinese medicine) formula, is reportedly effective in the treatment of patients with cerebral ischemic insults. ...
BACKGROUND: Chotosan (CTS, Diaoteng San), a Kampo medicine (ie Chinese medicine) formula, is reportedly effective in the treatment of …
62 results